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Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu(2+), Mn(2+), Zn(2+) and Co(2+) Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity
The interactions of transition metals with the prion protein (PrP) are well-documented and characterized, however, there is no consensus on their role in either the physiology of PrP or PrP-related neurodegenerative disorders. PrP has been reported to protect cells from the toxic stimuli of metals....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591282/ https://www.ncbi.nlm.nih.gov/pubmed/26426582 http://dx.doi.org/10.1371/journal.pone.0139219 |