Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products

Fungal polyketides are a diverse class of natural products, or secondary metabolites (SMs), with a wide range of bioactivities often associated with toxicity. Here, we focus on a group of non-reducing polyketide synthases (NR-PKSs) in the fungal phylum Ascomycota that lack a thioesterase domain for...

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Detalles Bibliográficos
Autores principales: Throckmorton, Kurt, Wiemann, Philipp, Keller, Nancy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591646/
https://www.ncbi.nlm.nih.gov/pubmed/26378577
http://dx.doi.org/10.3390/toxins7093572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591646/
https://www.ncbi.nlm.nih.gov/pubmed/26378577
http://dx.doi.org/10.3390/toxins7093572

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