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Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790
BACKGROUND: Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involve...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591702/ https://www.ncbi.nlm.nih.gov/pubmed/26435700 http://dx.doi.org/10.1186/s12950-015-0100-5 |
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author | Schneider, Simon Hoppmann, Petra Koch, Werner Kemmner, Stephan Schmaderer, Christoph Renders, Lutz Kastrati, Adnan Laugwitz, Karl-Ludwig Heemann, Uwe Baumann, Marcus |
author_facet | Schneider, Simon Hoppmann, Petra Koch, Werner Kemmner, Stephan Schmaderer, Christoph Renders, Lutz Kastrati, Adnan Laugwitz, Karl-Ludwig Heemann, Uwe Baumann, Marcus |
author_sort | Schneider, Simon |
collection | PubMed |
description | BACKGROUND: Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development of hypertension. We hypothesized that TLR4 ligands are involved in obesity-associated hypertension and investigated the TLR4 single nucleotide polymorphism (SNP rs 498790). This SNP is frequent, associated with cardiovascular disease and characterized by blunted response upon exposure to TLR4 ligands. METHODS: We investigated 3657 patients undergoing coronary angiography. Blood pressure was determined in standardized manner prior angiography. The diagnosis of hypertension was based on record data. Patients were characterized for TLR4 single nucleotide polymorphism (SNP) rs4986790. Patients were stratified according to quartiles of Body mass index (BMI) and according to the polymorphism. The association between the TLR4 polymorphism and blood pressure in obese patients (BMI > 30 kg/m(2)) was investigated by multivariate regression analysis. RESULTS: Out of 3657 patients 3017 patients fulfilled inclusion criteria. In the whole cohort a significant increase of SBP, pulse pressure and diagnosis of hypertension was observed across BMI quartiles. By contrast, no significant increase of SBP, pulse pressure or diagnosis of hypertension was observed in the 319 cases with TLR4 SNP rs4986790 across BMI quartiles. These obese cases had significantly lower SBP, lower pulse pressure (7.0 and 7.6 mmHg) and less diagnosis of hypertension as controls. In obesity the TLR4 SNP rs4986790 was an independent predictor of SBP. CONCLUSION: Systolic blood pressure increase with obesity was blunted in cases with TLR4 SNP rs4986790. |
format | Online Article Text |
id | pubmed-4591702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45917022015-10-03 Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790 Schneider, Simon Hoppmann, Petra Koch, Werner Kemmner, Stephan Schmaderer, Christoph Renders, Lutz Kastrati, Adnan Laugwitz, Karl-Ludwig Heemann, Uwe Baumann, Marcus J Inflamm (Lond) Research BACKGROUND: Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development of hypertension. We hypothesized that TLR4 ligands are involved in obesity-associated hypertension and investigated the TLR4 single nucleotide polymorphism (SNP rs 498790). This SNP is frequent, associated with cardiovascular disease and characterized by blunted response upon exposure to TLR4 ligands. METHODS: We investigated 3657 patients undergoing coronary angiography. Blood pressure was determined in standardized manner prior angiography. The diagnosis of hypertension was based on record data. Patients were characterized for TLR4 single nucleotide polymorphism (SNP) rs4986790. Patients were stratified according to quartiles of Body mass index (BMI) and according to the polymorphism. The association between the TLR4 polymorphism and blood pressure in obese patients (BMI > 30 kg/m(2)) was investigated by multivariate regression analysis. RESULTS: Out of 3657 patients 3017 patients fulfilled inclusion criteria. In the whole cohort a significant increase of SBP, pulse pressure and diagnosis of hypertension was observed across BMI quartiles. By contrast, no significant increase of SBP, pulse pressure or diagnosis of hypertension was observed in the 319 cases with TLR4 SNP rs4986790 across BMI quartiles. These obese cases had significantly lower SBP, lower pulse pressure (7.0 and 7.6 mmHg) and less diagnosis of hypertension as controls. In obesity the TLR4 SNP rs4986790 was an independent predictor of SBP. CONCLUSION: Systolic blood pressure increase with obesity was blunted in cases with TLR4 SNP rs4986790. BioMed Central 2015-10-01 /pmc/articles/PMC4591702/ /pubmed/26435700 http://dx.doi.org/10.1186/s12950-015-0100-5 Text en © Schneider et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Schneider, Simon Hoppmann, Petra Koch, Werner Kemmner, Stephan Schmaderer, Christoph Renders, Lutz Kastrati, Adnan Laugwitz, Karl-Ludwig Heemann, Uwe Baumann, Marcus Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790 |
title | Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790 |
title_full | Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790 |
title_fullStr | Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790 |
title_full_unstemmed | Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790 |
title_short | Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790 |
title_sort | obesity-associated hypertension is ameliorated in patients with tlr4 single nucleotide polymorphism (snp) rs4986790 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591702/ https://www.ncbi.nlm.nih.gov/pubmed/26435700 http://dx.doi.org/10.1186/s12950-015-0100-5 |
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