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Parasite clearance after malaria therapy: staying a step ahead of drug resistance

The discovery and development of the artemisinin class of antimalarial drugs is one of the great recent success stories of global health. However, after at least two decades of successful use, resistance has finally emerged and appears to be spreading rapidly throughout South-East Asia in spite of o...

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Autor principal: Karunajeewa, Harin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591708/
https://www.ncbi.nlm.nih.gov/pubmed/26429335
http://dx.doi.org/10.1186/s12916-015-0486-1
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author Karunajeewa, Harin A.
author_facet Karunajeewa, Harin A.
author_sort Karunajeewa, Harin A.
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description The discovery and development of the artemisinin class of antimalarial drugs is one of the great recent success stories of global health. However, after at least two decades of successful use, resistance has finally emerged and appears to be spreading rapidly throughout South-East Asia in spite of our best efforts at containment. If this were also to occur in Africa, it would have disastrous implications for the continent subject to the world’s greatest burden of Plasmodium falciparum. The earliest indications of incipient artemisinin resistance may be a slowing of the rate at which parasites are cleared from the blood following treatment. The Worldwide Antimalarial Resistance Network have analysed data from 29,493 patients from 84 clinical trials in order to define the nature and determinants of early parasite clearance following artemisinin-based treatment in African populations. In doing so, they lay the foundation for systems intended to enable the earliest possible detection of emerging artemisinin resistance in Africa. Please see related article: http://www.biomedcentral.com/1741-7015/13/212
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spelling pubmed-45917082015-10-03 Parasite clearance after malaria therapy: staying a step ahead of drug resistance Karunajeewa, Harin A. BMC Med Commentary The discovery and development of the artemisinin class of antimalarial drugs is one of the great recent success stories of global health. However, after at least two decades of successful use, resistance has finally emerged and appears to be spreading rapidly throughout South-East Asia in spite of our best efforts at containment. If this were also to occur in Africa, it would have disastrous implications for the continent subject to the world’s greatest burden of Plasmodium falciparum. The earliest indications of incipient artemisinin resistance may be a slowing of the rate at which parasites are cleared from the blood following treatment. The Worldwide Antimalarial Resistance Network have analysed data from 29,493 patients from 84 clinical trials in order to define the nature and determinants of early parasite clearance following artemisinin-based treatment in African populations. In doing so, they lay the foundation for systems intended to enable the earliest possible detection of emerging artemisinin resistance in Africa. Please see related article: http://www.biomedcentral.com/1741-7015/13/212 BioMed Central 2015-10-02 /pmc/articles/PMC4591708/ /pubmed/26429335 http://dx.doi.org/10.1186/s12916-015-0486-1 Text en © Karunajeewa. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Karunajeewa, Harin A.
Parasite clearance after malaria therapy: staying a step ahead of drug resistance
title Parasite clearance after malaria therapy: staying a step ahead of drug resistance
title_full Parasite clearance after malaria therapy: staying a step ahead of drug resistance
title_fullStr Parasite clearance after malaria therapy: staying a step ahead of drug resistance
title_full_unstemmed Parasite clearance after malaria therapy: staying a step ahead of drug resistance
title_short Parasite clearance after malaria therapy: staying a step ahead of drug resistance
title_sort parasite clearance after malaria therapy: staying a step ahead of drug resistance
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591708/
https://www.ncbi.nlm.nih.gov/pubmed/26429335
http://dx.doi.org/10.1186/s12916-015-0486-1
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