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Ligand uptake in Mycobacterium tuberculosis truncated hemoglobins is controlled by both internal tunnels and active site water molecules

Mycobacterium tuberculosis, the causative agent of human tuberculosis, has two proteins belonging to the truncated hemoglobin (trHb) family. Mt-trHbN presents well-defined internal hydrophobic tunnels that allow O (2) and (•)NO to migrate easily from the solvent to the active site, whereas Mt-trHbO...

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Detalles Bibliográficos
Autores principales:	Boron, Ignacio, Bustamante, Juan Pablo, Davidge, Kelly S, Singh, Sandip, Bowman, Lesley AH, Tinajero-Trejo, Mariana, Carballal, Sebastián, Radi, Rafael, Poole, Robert K, Dikshit, Kanak, Estrin, Dario A, Marti, Marcelo A, Boechi, Leonardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591903/ https://www.ncbi.nlm.nih.gov/pubmed/26478812 http://dx.doi.org/10.12688/f1000research.5921.2

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