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MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea

Most cases of Middle East Respiratory Syndrome (MERS) infection in Korea (outbreak: May 11-July 4, 2015) occurred in hospital settings, with uncertain transmission modes in some cases. We performed an in-depth investigation epidemiological survey on the 178th case to determine the precise mode of tr...

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Autores principales: Chang, Kyujin, Ki, Moran, Lee, Eun Gyu, Lee, Soon Young, Yoo, Byoungin, Choi, Jong Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Epidemiology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591909/
https://www.ncbi.nlm.nih.gov/pubmed/26493651
http://dx.doi.org/10.4178/epih/e2015036
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author Chang, Kyujin
Ki, Moran
Lee, Eun Gyu
Lee, Soon Young
Yoo, Byoungin
Choi, Jong Hyuk
author_facet Chang, Kyujin
Ki, Moran
Lee, Eun Gyu
Lee, Soon Young
Yoo, Byoungin
Choi, Jong Hyuk
author_sort Chang, Kyujin
collection PubMed
description Most cases of Middle East Respiratory Syndrome (MERS) infection in Korea (outbreak: May 11-July 4, 2015) occurred in hospital settings, with uncertain transmission modes in some cases. We performed an in-depth investigation epidemiological survey on the 178th case to determine the precise mode of transmission. A 29- year-old man living in Pyeongtaek presented on June 16 with a febrile sensation, chills, and myalgia. Upon confirmatory diagnosis on June 23, he was treated in an isolation room and discharged on July 2 after cure. An epidemiological investigation of all possible infection routes indicated two likely modes of transmission: exposure to MERS in Pyeongtaek St. Mary’s Hospital during a visit to his hospitalized father (May 18-29), and infection through frequent contact with his father between the latter’s referral to Pyeongtaek Good Samaritan Bagae Hospital for treatment without confirmatory diagnosis until his death (May 29-June 6). Although lack of clear proof or evidence to the contrary does not allow a definitive conclusion, all other possibilities could be excluded by epidemiological inferences. While it is impossible to trace back the modes of transmission of all cases in a large-scale outbreak, case-by-case tracking and isolation of infected individuals and those in close contact with them is important in preventing the spread. Efforts should be made to establish a methodology for rapid tracking of all possible contacts and elimination-based identification of the precise modes of transmission.
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spelling pubmed-45919092015-11-24 MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea Chang, Kyujin Ki, Moran Lee, Eun Gyu Lee, Soon Young Yoo, Byoungin Choi, Jong Hyuk Epidemiol Health MERS Most cases of Middle East Respiratory Syndrome (MERS) infection in Korea (outbreak: May 11-July 4, 2015) occurred in hospital settings, with uncertain transmission modes in some cases. We performed an in-depth investigation epidemiological survey on the 178th case to determine the precise mode of transmission. A 29- year-old man living in Pyeongtaek presented on June 16 with a febrile sensation, chills, and myalgia. Upon confirmatory diagnosis on June 23, he was treated in an isolation room and discharged on July 2 after cure. An epidemiological investigation of all possible infection routes indicated two likely modes of transmission: exposure to MERS in Pyeongtaek St. Mary’s Hospital during a visit to his hospitalized father (May 18-29), and infection through frequent contact with his father between the latter’s referral to Pyeongtaek Good Samaritan Bagae Hospital for treatment without confirmatory diagnosis until his death (May 29-June 6). Although lack of clear proof or evidence to the contrary does not allow a definitive conclusion, all other possibilities could be excluded by epidemiological inferences. While it is impossible to trace back the modes of transmission of all cases in a large-scale outbreak, case-by-case tracking and isolation of infected individuals and those in close contact with them is important in preventing the spread. Efforts should be made to establish a methodology for rapid tracking of all possible contacts and elimination-based identification of the precise modes of transmission. Korean Society of Epidemiology 2015-08-15 /pmc/articles/PMC4591909/ /pubmed/26493651 http://dx.doi.org/10.4178/epih/e2015036 Text en ©2015, Korean Society of Epidemiology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle MERS
Chang, Kyujin
Ki, Moran
Lee, Eun Gyu
Lee, Soon Young
Yoo, Byoungin
Choi, Jong Hyuk
MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea
title MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea
title_full MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea
title_fullStr MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea
title_full_unstemmed MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea
title_short MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea
title_sort mers epidemiological investigation to detect potential mode of transmission in the 178th mers confirmed case in pyeongtaek, korea
topic MERS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591909/
https://www.ncbi.nlm.nih.gov/pubmed/26493651
http://dx.doi.org/10.4178/epih/e2015036
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