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Nanoparticles of barium induce apoptosis in human phagocytes

PURPOSE: Nutrients and immunological factors of breast milk are essential for newborn growth and the development of their immune system, but this secretion can contain organic and inorganic toxins such as barium. Colostrum contamination with barium is an important issue to investigate because this n...

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Autores principales: Mores, Luana, França, Eduardo Luzia, Silva, Núbia Andrade, Suchara, Eliane Aparecida, Honorio-França, Adenilda Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592030/
https://www.ncbi.nlm.nih.gov/pubmed/26451108
http://dx.doi.org/10.2147/IJN.S90382
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author Mores, Luana
França, Eduardo Luzia
Silva, Núbia Andrade
Suchara, Eliane Aparecida
Honorio-França, Adenilda Cristina
author_facet Mores, Luana
França, Eduardo Luzia
Silva, Núbia Andrade
Suchara, Eliane Aparecida
Honorio-França, Adenilda Cristina
author_sort Mores, Luana
collection PubMed
description PURPOSE: Nutrients and immunological factors of breast milk are essential for newborn growth and the development of their immune system, but this secretion can contain organic and inorganic toxins such as barium. Colostrum contamination with barium is an important issue to investigate because this naturally occurring element is also associated with human activity and industrial pollution. The study evaluated the administration of barium nanoparticles to colostrum, assessing the viability and functional activity of colostral mononuclear phagocytes. METHODS: Colostrum was collected from 24 clinically healthy women (aged 18–35 years). Cell viability, superoxide release, intracellular Ca(2+) release, and phagocyte apoptosis were analyzed in the samples. RESULTS: Treatment with barium lowered mononuclear phagocyte viability, increased superoxide release, and reduced intracellular calcium release. In addition, barium increased cell death by apoptosis. CONCLUSION: These data suggest that nanoparticles of barium in colostrum are toxic to cells, showing the importance of avoiding exposure to this element.
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spelling pubmed-45920302015-10-08 Nanoparticles of barium induce apoptosis in human phagocytes Mores, Luana França, Eduardo Luzia Silva, Núbia Andrade Suchara, Eliane Aparecida Honorio-França, Adenilda Cristina Int J Nanomedicine Original Research PURPOSE: Nutrients and immunological factors of breast milk are essential for newborn growth and the development of their immune system, but this secretion can contain organic and inorganic toxins such as barium. Colostrum contamination with barium is an important issue to investigate because this naturally occurring element is also associated with human activity and industrial pollution. The study evaluated the administration of barium nanoparticles to colostrum, assessing the viability and functional activity of colostral mononuclear phagocytes. METHODS: Colostrum was collected from 24 clinically healthy women (aged 18–35 years). Cell viability, superoxide release, intracellular Ca(2+) release, and phagocyte apoptosis were analyzed in the samples. RESULTS: Treatment with barium lowered mononuclear phagocyte viability, increased superoxide release, and reduced intracellular calcium release. In addition, barium increased cell death by apoptosis. CONCLUSION: These data suggest that nanoparticles of barium in colostrum are toxic to cells, showing the importance of avoiding exposure to this element. Dove Medical Press 2015-09-28 /pmc/articles/PMC4592030/ /pubmed/26451108 http://dx.doi.org/10.2147/IJN.S90382 Text en © 2015 Mores et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Mores, Luana
França, Eduardo Luzia
Silva, Núbia Andrade
Suchara, Eliane Aparecida
Honorio-França, Adenilda Cristina
Nanoparticles of barium induce apoptosis in human phagocytes
title Nanoparticles of barium induce apoptosis in human phagocytes
title_full Nanoparticles of barium induce apoptosis in human phagocytes
title_fullStr Nanoparticles of barium induce apoptosis in human phagocytes
title_full_unstemmed Nanoparticles of barium induce apoptosis in human phagocytes
title_short Nanoparticles of barium induce apoptosis in human phagocytes
title_sort nanoparticles of barium induce apoptosis in human phagocytes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592030/
https://www.ncbi.nlm.nih.gov/pubmed/26451108
http://dx.doi.org/10.2147/IJN.S90382
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