Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?

Glioblastoma Multiforme, the most common and aggressive primary brain tumor, remains incurable despite of the advent of modern surgical and medical treatments. This poor prognosis depends by the recurrence after surgery and intrinsic or acquired resistance to chemotherapy and radiotherapy. Nitric ox...

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Autores principales: Altieri, R., Fontanella, M., Agnoletti, A., Panciani, P.P., Spena, G., Crobeddu, E., Pilloni, G., Tardivo, V., Lanotte, M., Zenga, F., Ducati, A., Garbossa, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Universitài Salerno 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592044/
https://www.ncbi.nlm.nih.gov/pubmed/26535188
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author Altieri, R.
Fontanella, M.
Agnoletti, A.
Panciani, P.P.
Spena, G.
Crobeddu, E.
Pilloni, G.
Tardivo, V.
Lanotte, M.
Zenga, F.
Ducati, A.
Garbossa, D.
author_facet Altieri, R.
Fontanella, M.
Agnoletti, A.
Panciani, P.P.
Spena, G.
Crobeddu, E.
Pilloni, G.
Tardivo, V.
Lanotte, M.
Zenga, F.
Ducati, A.
Garbossa, D.
author_sort Altieri, R.
collection PubMed
description Glioblastoma Multiforme, the most common and aggressive primary brain tumor, remains incurable despite of the advent of modern surgical and medical treatments. This poor prognosis depends by the recurrence after surgery and intrinsic or acquired resistance to chemotherapy and radiotherapy. Nitric oxide is a small molecule that plays a key roles in glioma pathophysiology. Many researches showing that NO is involved in induction of apoptosis, radiosensitization and chemosensitization. Therefore, NO role, if clarified, may improve the knowledge about this unsolved puzzle called GBM.
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spelling pubmed-45920442015-11-03 Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ? Altieri, R. Fontanella, M. Agnoletti, A. Panciani, P.P. Spena, G. Crobeddu, E. Pilloni, G. Tardivo, V. Lanotte, M. Zenga, F. Ducati, A. Garbossa, D. Transl Med UniSa Articles Glioblastoma Multiforme, the most common and aggressive primary brain tumor, remains incurable despite of the advent of modern surgical and medical treatments. This poor prognosis depends by the recurrence after surgery and intrinsic or acquired resistance to chemotherapy and radiotherapy. Nitric oxide is a small molecule that plays a key roles in glioma pathophysiology. Many researches showing that NO is involved in induction of apoptosis, radiosensitization and chemosensitization. Therefore, NO role, if clarified, may improve the knowledge about this unsolved puzzle called GBM. Universitài Salerno 2014-09-01 /pmc/articles/PMC4592044/ /pubmed/26535188 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Altieri, R.
Fontanella, M.
Agnoletti, A.
Panciani, P.P.
Spena, G.
Crobeddu, E.
Pilloni, G.
Tardivo, V.
Lanotte, M.
Zenga, F.
Ducati, A.
Garbossa, D.
Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?
title Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?
title_full Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?
title_fullStr Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?
title_full_unstemmed Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?
title_short Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?
title_sort role of nitric oxide in glioblastoma therapy: another step to resolve the terrible puzzle ?
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592044/
https://www.ncbi.nlm.nih.gov/pubmed/26535188
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