Cargando…

Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood

With several therapeutic approaches in development for Huntington's disease, there is a need for easily accessible biomarkers to monitor disease progression and therapy response. We performed next-generation sequencing-based transcriptome analysis of total RNA from peripheral blood of 91 mutati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mastrokolias, Anastasios, Ariyurek, Yavuz, Goeman, Jelle J, van Duijn, Erik, Roos, Raymund AC, van der Mast, Roos C, van Ommen, GertJan B, den Dunnen, Johan T, 't Hoen, Peter AC, van Roon-Mom, Willeke MC
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592077/ https://www.ncbi.nlm.nih.gov/pubmed/25626709 http://dx.doi.org/10.1038/ejhg.2014.281

Ejemplares similares

Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
por: Mastrokolias, Anastasios, et al.
Publicado: (2012)

Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington’s disease peripheral blood samples
por: Mastrokolias, Anastasios, et al.
Publicado: (2016)

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease
por: van Roon-Mom, Willeke MC, et al.
Publicado: (2008)

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain
por: Mina, Eleni, et al.
Publicado: (2016)

Juvenile‐Onset Huntington Disease Pathophysiology and Neurodevelopment: A Review
por: Bakels, Hannah S., et al.
Publicado: (2021)

New methods for next generation sequencing based microRNA expression profiling
por: Buermans, Henk PJ, et al.
Publicado: (2010)

Making (anti-) sense out of huntingtin levels in Huntington disease
por: Evers, Melvin M, et al.
Publicado: (2015)

Bioenergetics in fibroblasts of patients with Huntington disease are associated with age at onset
por: Gardiner, Sarah L., et al.
Publicado: (2018)

Huntington's disease: a clinical review
por: Roos, Raymund AC
Publicado: (2010)

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates
por: Schut, Menno H., et al.
Publicado: (2017)

Cost-effective HRMA pre-sequence typing of clone libraries; application to phage display selection
por: Pepers, Barry A, et al.
Publicado: (2009)

The MID1 Protein: A Promising Therapeutic Target in Huntington’s Disease
por: Heinz, Annika, et al.
Publicado: (2021)

Aspiration pneumonia and death in Huntington’s disease
por: Heemskerk, Anne-Wil, et al.
Publicado: (2012)

Tissue-specific transcript annotation and expression profiling with complementary next-generation sequencing technologies
por: Hestand, Matthew S., et al.
Publicado: (2010)

Can subtle changes in gene expression be consistently detected with different microarray platforms?
por: Pedotti, Paola, et al.
Publicado: (2008)

CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes
por: Hestand, Matthew S, et al.
Publicado: (2008)

Machine learning in Huntington’s disease: exploring the Enroll-HD dataset for prognosis and driving capability prediction
por: Ouwerkerk, Jasper, et al.
Publicado: (2023)

Cystathionine Levels in Patients With Huntington Disease
por: Aziz, N.A., et al.
Publicado: (2015)

Targeting Several CAG Expansion Diseases by a Single Antisense Oligonucleotide
por: Evers, Melvin M., et al.
Publicado: (2011)

Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia
por: Kenkhuis, Boyd, et al.
Publicado: (2022)

Early grey matter changes in structural covariance networks in Huntington's disease
por: Coppen, Emma M., et al.
Publicado: (2016)

Literature-aided meta-analysis of microarray data: a compendium study on muscle development and disease
por: Jelier, Rob, et al.
Publicado: (2008)

Selection and characterization of llama single domain antibodies against N-terminal huntingtin
por: Schut, Menno H., et al.
Publicado: (2014)

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation
por: Ramos, Yolande F. M., et al.
Publicado: (2010)

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease
por: Hensman Moss, Davina J., et al.
Publicado: (2017)

Dynamics of the connectome in Huntington's disease: A longitudinal diffusion MRI study
por: Odish, Omar F.F., et al.
Publicado: (2015)

Pathological characterization of T2*-weighted MRI contrast in the striatum of Huntington’s disease patients
por: Bulk, Marjolein, et al.
Publicado: (2020)

MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease
por: Jurgens, Caroline K, et al.
Publicado: (2010)

Post‐mortem 7T MR imaging and neuropathology in middle stage juvenile‐onset Huntington disease: A case report
por: Bakels, Hannah S., et al.
Publicado: (2022)

Statistical method for modeling sequencing data from different technologies in longitudinal studies with application to Huntington disease
por: Fuady, Angga M., et al.
Publicado: (2020)

Determining the quality and complexity of next-generation sequencing data without a reference genome
por: Anvar, Seyed Yahya, et al.
Publicado: (2014)

Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms
por: 't Hoen, Peter A. C., et al.
Publicado: (2008)

Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study
por: Baake, Verena, et al.
Publicado: (2018)

Seven-year clinical follow-up of premanifest carriers of Huntington's disease
por: Hart, Ellen, et al.
Publicado: (2011)

Correction: DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts
por: Zhernakova, Daria V., et al.
Publicado: (2013)

DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts
por: Zhernakova, Daria V., et al.
Publicado: (2013)

EEG may serve as a biomarker in Huntington’s disease using machine learning automatic classification
por: Odish, Omar F. F., et al.
Publicado: (2018)

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model
por: van Hagen, Martijn, et al.
Publicado: (2017)

Reduced functional brain connectivity prior to and after disease onset in Huntington's disease()()
por: Dumas, Eve M., et al.
Publicado: (2013)

Gene expression variation between mouse inbred strains
por: Turk, Rolf, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_dvtqrcdtvvilhs0gamdau3hntc