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Composition, Development, and Function of Uterine Innate Lymphoid Cells

Innate lymphoid cells (ILCs), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells in placentation and fetal growth, other uterine ILCs (uILCs) are likely to play roles in uterine physiology and pathology. In this article, we report o...

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Autores principales: Doisne, Jean-Marc, Balmas, Elisa, Boulenouar, Selma, Gaynor, Louise M., Kieckbusch, Jens, Gardner, Lucy, Hawkes, Delia A., Barbara, Cynthia F., Sharkey, Andrew M., Brady, Hugh J. M., Brosens, Jan J., Moffett, Ashley, Colucci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592103/
https://www.ncbi.nlm.nih.gov/pubmed/26371244
http://dx.doi.org/10.4049/jimmunol.1500689
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author Doisne, Jean-Marc
Balmas, Elisa
Boulenouar, Selma
Gaynor, Louise M.
Kieckbusch, Jens
Gardner, Lucy
Hawkes, Delia A.
Barbara, Cynthia F.
Sharkey, Andrew M.
Brady, Hugh J. M.
Brosens, Jan J.
Moffett, Ashley
Colucci, Francesco
author_facet Doisne, Jean-Marc
Balmas, Elisa
Boulenouar, Selma
Gaynor, Louise M.
Kieckbusch, Jens
Gardner, Lucy
Hawkes, Delia A.
Barbara, Cynthia F.
Sharkey, Andrew M.
Brady, Hugh J. M.
Brosens, Jan J.
Moffett, Ashley
Colucci, Francesco
author_sort Doisne, Jean-Marc
collection PubMed
description Innate lymphoid cells (ILCs), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells in placentation and fetal growth, other uterine ILCs (uILCs) are likely to play roles in uterine physiology and pathology. In this article, we report on the composition of uILCs in the endometrium during the luteal phase and in the decidua during early pregnancy. Whereas nonkiller uILC1s and uILC2s are barely detectable in mouse and not detected in humans, a sizeable population of uILC3s is found in human endometrium and decidua, which are mostly NCR(+) and partially overlap with previously described IL-22–producing uterine NK cells. Development of mouse uILC3 is Nfil3 independent, suggesting unique features of uILCs. Indeed, although the cytokine production profile of mouse uILCs recapitulates that described in other tissues, IL-5, IL-17, and IL-22 are constitutively produced by uILC2s and uILC3s. This study lays the foundation to understand how ILCs function in the specialized uterine mucosa, both in tissue homeostasis and barrier immunity and during pregnancy.
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spelling pubmed-45921032015-10-07 Composition, Development, and Function of Uterine Innate Lymphoid Cells Doisne, Jean-Marc Balmas, Elisa Boulenouar, Selma Gaynor, Louise M. Kieckbusch, Jens Gardner, Lucy Hawkes, Delia A. Barbara, Cynthia F. Sharkey, Andrew M. Brady, Hugh J. M. Brosens, Jan J. Moffett, Ashley Colucci, Francesco J Immunol Innate Immunity and Inflammation Innate lymphoid cells (ILCs), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells in placentation and fetal growth, other uterine ILCs (uILCs) are likely to play roles in uterine physiology and pathology. In this article, we report on the composition of uILCs in the endometrium during the luteal phase and in the decidua during early pregnancy. Whereas nonkiller uILC1s and uILC2s are barely detectable in mouse and not detected in humans, a sizeable population of uILC3s is found in human endometrium and decidua, which are mostly NCR(+) and partially overlap with previously described IL-22–producing uterine NK cells. Development of mouse uILC3 is Nfil3 independent, suggesting unique features of uILCs. Indeed, although the cytokine production profile of mouse uILCs recapitulates that described in other tissues, IL-5, IL-17, and IL-22 are constitutively produced by uILC2s and uILC3s. This study lays the foundation to understand how ILCs function in the specialized uterine mucosa, both in tissue homeostasis and barrier immunity and during pregnancy. AAI 2015-10-15 2015-09-14 /pmc/articles/PMC4592103/ /pubmed/26371244 http://dx.doi.org/10.4049/jimmunol.1500689 Text en Copyright © 2015 The Authors This is an open-access article distributed under the terms of the CC-BY 3.0 Unported license.
spellingShingle Innate Immunity and Inflammation
Doisne, Jean-Marc
Balmas, Elisa
Boulenouar, Selma
Gaynor, Louise M.
Kieckbusch, Jens
Gardner, Lucy
Hawkes, Delia A.
Barbara, Cynthia F.
Sharkey, Andrew M.
Brady, Hugh J. M.
Brosens, Jan J.
Moffett, Ashley
Colucci, Francesco
Composition, Development, and Function of Uterine Innate Lymphoid Cells
title Composition, Development, and Function of Uterine Innate Lymphoid Cells
title_full Composition, Development, and Function of Uterine Innate Lymphoid Cells
title_fullStr Composition, Development, and Function of Uterine Innate Lymphoid Cells
title_full_unstemmed Composition, Development, and Function of Uterine Innate Lymphoid Cells
title_short Composition, Development, and Function of Uterine Innate Lymphoid Cells
title_sort composition, development, and function of uterine innate lymphoid cells
topic Innate Immunity and Inflammation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592103/
https://www.ncbi.nlm.nih.gov/pubmed/26371244
http://dx.doi.org/10.4049/jimmunol.1500689
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