Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4(+) T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been propo...

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Detalles Bibliográficos
Autores principales: Arnold, Laurence H., Groom, Harriet C. T., Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J., Ordonez, Paula, Mann, Melanie C., Rueschenbaum, Sabrina, Goldstone, David C., Pennell, Simon, Howell, Steven A., Stoye, Jonathan P., Webb, Michelle, Taylor, Ian A., Bishop, Kate N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592219/
https://www.ncbi.nlm.nih.gov/pubmed/26431200
http://dx.doi.org/10.1371/journal.ppat.1005194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592219/
https://www.ncbi.nlm.nih.gov/pubmed/26431200
http://dx.doi.org/10.1371/journal.ppat.1005194

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