Can serum albumin level affect the pharmacological action of tolvaptan in patients with liver cirrhosis? A post hoc analysis of previous clinical trials in Japan

BACKGROUND: Patients with hypoalbuminemia often fail to respond to increased doses of loop diuretics. We therefore performed a post hoc analysis to investigate the pharmacological action of tolvaptan and whether it is dependent on the serum albumin level. METHODS: This analysis was based on four pre...

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Detalles Bibliográficos
Autores principales: Sakaida, Isao, Nakajima, Koji, Okita, Kiwamu, Hori, Masatsugu, Izumi, Tohru, Sakurai, Masaya, Shibasaki, Yoshiyuki, Tachikawa, Sayaka, Tsubouchi, Hidetsugu, Oka, Hiromi, Kobayashi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2015
Materias:
Original Article—Liver, Pancreas, and Biliary Tract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592499/
https://www.ncbi.nlm.nih.gov/pubmed/25689936
http://dx.doi.org/10.1007/s00535-015-1052-5

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