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Connecting the Dots: Linking Osteocyte Activity and Therapeutic Modulation of Sclerostin by Extending a Multiscale Systems Model

The goal of this work was to extend a mathematical, multiscale systems model of bone function, remodeling, and health in order to explore hypotheses related to therapeutic modulation of sclerostin and quantitatively describe purported osteocyte activity within bone remodeling events. A pharmacokinet...

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Detalles Bibliográficos
Autores principales:	Eudy, RJ, Gastonguay, MR, Baron, KT, Riggs, MM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592532/ https://www.ncbi.nlm.nih.gov/pubmed/26451332 http://dx.doi.org/10.1002/psp4.12013

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