MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models

Quantitative systems pharmacology (QSP) models are progressively entering the arena of contemporary pharmacology. The efficient implementation and evaluation of complex QSP models necessitates the development of flexible computational tools that are built into QSP mainstream software. To this end, w...

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Detalles Bibliográficos
Autores principales: Biliouris, K, Lavielle, M, Trame, MN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Tutorials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592534/
https://www.ncbi.nlm.nih.gov/pubmed/26451334
http://dx.doi.org/10.1002/psp4.12011
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author Biliouris, K
Lavielle, M
Trame, MN
author_facet Biliouris, K
Lavielle, M
Trame, MN
author_sort Biliouris, K
collection PubMed
description Quantitative systems pharmacology (QSP) models are progressively entering the arena of contemporary pharmacology. The efficient implementation and evaluation of complex QSP models necessitates the development of flexible computational tools that are built into QSP mainstream software. To this end, we present MatVPC, a versatile MATLAB-based tool that accommodates QSP models of any complexity level. MatVPC executes Monte Carlo simulations as well as automatic construction of visual predictive checks (VPCs) and quantified VPCs (QVPCs).
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spelling pubmed-45925342015-10-08 MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models Biliouris, K Lavielle, M Trame, MN CPT Pharmacometrics Syst Pharmacol Tutorials Quantitative systems pharmacology (QSP) models are progressively entering the arena of contemporary pharmacology. The efficient implementation and evaluation of complex QSP models necessitates the development of flexible computational tools that are built into QSP mainstream software. To this end, we present MatVPC, a versatile MATLAB-based tool that accommodates QSP models of any complexity level. MatVPC executes Monte Carlo simulations as well as automatic construction of visual predictive checks (VPCs) and quantified VPCs (QVPCs). John Wiley & Sons, Ltd 2015-09 2015-08-22 /pmc/articles/PMC4592534/ /pubmed/26451334 http://dx.doi.org/10.1002/psp4.12011 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Tutorials
Biliouris, K
Lavielle, M
Trame, MN
MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models
title MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models
title_full MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models
title_fullStr MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models
title_full_unstemmed MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models
title_short MatVPC: A User-Friendly MATLAB-Based Tool for the Simulation and Evaluation of Systems Pharmacology Models
title_sort matvpc: a user-friendly matlab-based tool for the simulation and evaluation of systems pharmacology models
topic Tutorials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592534/
https://www.ncbi.nlm.nih.gov/pubmed/26451334
http://dx.doi.org/10.1002/psp4.12011
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