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Functional Importance of Mobile Ribosomal Proteins
Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not str...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592705/ https://www.ncbi.nlm.nih.gov/pubmed/26457300 http://dx.doi.org/10.1155/2015/539238 |
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author | Chang, Kai-Chun Wen, Jin-Der Yang, Lee-Wei |
author_facet | Chang, Kai-Chun Wen, Jin-Der Yang, Lee-Wei |
author_sort | Chang, Kai-Chun |
collection | PubMed |
description | Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved due to their high flexibility, which hinders the efforts in their functional elucidation. Owing to recent advances in cryo-electron microscopy, single-molecule techniques, and theoretical modeling, much has been learned about the dynamics of these r-proteins. Surprisingly, allosteric regulations have been found in between spatially separated components as distant as those in the opposite sides of the ribosome. Here, we focus on the functional roles and intricate regulations of the mobile L1 and L12 stalks and L9 and S1 proteins. Conformational flexibility also enables versatile functions for r-proteins beyond translation. The arrangement of r-proteins may be under evolutionary pressure that fine-tunes mass distributions for optimal structural dynamics and catalytic activity of the ribosome. |
format | Online Article Text |
id | pubmed-4592705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45927052015-10-11 Functional Importance of Mobile Ribosomal Proteins Chang, Kai-Chun Wen, Jin-Der Yang, Lee-Wei Biomed Res Int Review Article Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved due to their high flexibility, which hinders the efforts in their functional elucidation. Owing to recent advances in cryo-electron microscopy, single-molecule techniques, and theoretical modeling, much has been learned about the dynamics of these r-proteins. Surprisingly, allosteric regulations have been found in between spatially separated components as distant as those in the opposite sides of the ribosome. Here, we focus on the functional roles and intricate regulations of the mobile L1 and L12 stalks and L9 and S1 proteins. Conformational flexibility also enables versatile functions for r-proteins beyond translation. The arrangement of r-proteins may be under evolutionary pressure that fine-tunes mass distributions for optimal structural dynamics and catalytic activity of the ribosome. Hindawi Publishing Corporation 2015 2015-09-20 /pmc/articles/PMC4592705/ /pubmed/26457300 http://dx.doi.org/10.1155/2015/539238 Text en Copyright © 2015 Kai-Chun Chang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chang, Kai-Chun Wen, Jin-Der Yang, Lee-Wei Functional Importance of Mobile Ribosomal Proteins |
title | Functional Importance of Mobile Ribosomal Proteins |
title_full | Functional Importance of Mobile Ribosomal Proteins |
title_fullStr | Functional Importance of Mobile Ribosomal Proteins |
title_full_unstemmed | Functional Importance of Mobile Ribosomal Proteins |
title_short | Functional Importance of Mobile Ribosomal Proteins |
title_sort | functional importance of mobile ribosomal proteins |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592705/ https://www.ncbi.nlm.nih.gov/pubmed/26457300 http://dx.doi.org/10.1155/2015/539238 |
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