Cargando…

Functional Importance of Mobile Ribosomal Proteins

Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not str...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Kai-Chun, Wen, Jin-Der, Yang, Lee-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592705/
https://www.ncbi.nlm.nih.gov/pubmed/26457300
http://dx.doi.org/10.1155/2015/539238
_version_ 1782393229064273920
author Chang, Kai-Chun
Wen, Jin-Der
Yang, Lee-Wei
author_facet Chang, Kai-Chun
Wen, Jin-Der
Yang, Lee-Wei
author_sort Chang, Kai-Chun
collection PubMed
description Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved due to their high flexibility, which hinders the efforts in their functional elucidation. Owing to recent advances in cryo-electron microscopy, single-molecule techniques, and theoretical modeling, much has been learned about the dynamics of these r-proteins. Surprisingly, allosteric regulations have been found in between spatially separated components as distant as those in the opposite sides of the ribosome. Here, we focus on the functional roles and intricate regulations of the mobile L1 and L12 stalks and L9 and S1 proteins. Conformational flexibility also enables versatile functions for r-proteins beyond translation. The arrangement of r-proteins may be under evolutionary pressure that fine-tunes mass distributions for optimal structural dynamics and catalytic activity of the ribosome.
format Online
Article
Text
id pubmed-4592705
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-45927052015-10-11 Functional Importance of Mobile Ribosomal Proteins Chang, Kai-Chun Wen, Jin-Der Yang, Lee-Wei Biomed Res Int Review Article Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved due to their high flexibility, which hinders the efforts in their functional elucidation. Owing to recent advances in cryo-electron microscopy, single-molecule techniques, and theoretical modeling, much has been learned about the dynamics of these r-proteins. Surprisingly, allosteric regulations have been found in between spatially separated components as distant as those in the opposite sides of the ribosome. Here, we focus on the functional roles and intricate regulations of the mobile L1 and L12 stalks and L9 and S1 proteins. Conformational flexibility also enables versatile functions for r-proteins beyond translation. The arrangement of r-proteins may be under evolutionary pressure that fine-tunes mass distributions for optimal structural dynamics and catalytic activity of the ribosome. Hindawi Publishing Corporation 2015 2015-09-20 /pmc/articles/PMC4592705/ /pubmed/26457300 http://dx.doi.org/10.1155/2015/539238 Text en Copyright © 2015 Kai-Chun Chang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chang, Kai-Chun
Wen, Jin-Der
Yang, Lee-Wei
Functional Importance of Mobile Ribosomal Proteins
title Functional Importance of Mobile Ribosomal Proteins
title_full Functional Importance of Mobile Ribosomal Proteins
title_fullStr Functional Importance of Mobile Ribosomal Proteins
title_full_unstemmed Functional Importance of Mobile Ribosomal Proteins
title_short Functional Importance of Mobile Ribosomal Proteins
title_sort functional importance of mobile ribosomal proteins
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592705/
https://www.ncbi.nlm.nih.gov/pubmed/26457300
http://dx.doi.org/10.1155/2015/539238
work_keys_str_mv AT changkaichun functionalimportanceofmobileribosomalproteins
AT wenjinder functionalimportanceofmobileribosomalproteins
AT yangleewei functionalimportanceofmobileribosomalproteins