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Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse

Herein, we aimed to report a diffuse large B cell lymphoma (DLBCL) case that had extensive cutaneous relapse with no skin involvement previously. A 59-year-old man presented to hospital in April 2014 with fatigue, anorexia, fever, and anemia. Cervical lymph node biopsy revealed CD20+, BCL2+, MUM1+,...

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Autores principales: Malkan, Umit Yavuz, Gunes, Gursel, Yayar, Okan, Demiroglu, Haluk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592711/
https://www.ncbi.nlm.nih.gov/pubmed/26457084
http://dx.doi.org/10.1155/2015/137682
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author Malkan, Umit Yavuz
Gunes, Gursel
Yayar, Okan
Demiroglu, Haluk
author_facet Malkan, Umit Yavuz
Gunes, Gursel
Yayar, Okan
Demiroglu, Haluk
author_sort Malkan, Umit Yavuz
collection PubMed
description Herein, we aimed to report a diffuse large B cell lymphoma (DLBCL) case that had extensive cutaneous relapse with no skin involvement previously. A 59-year-old man presented to hospital in April 2014 with fatigue, anorexia, fever, and anemia. Cervical lymph node biopsy revealed CD20+, BCL2+, MUM1+, BCL6+ high grade B lymphoproliferative neoplasm. After FISH investigation, he was diagnosed as DLBCL. He was given 7 cycles of R-CHOP and achieved remission. However, in November 2014, he had emerging skin lesions that cover nearly all of his body. A control PET-CT revealed diffuse cutaneous involvement. CD20+, BCL2+, MUM1+, BCL6+ high grade B cell lymphoma infiltration was detected with skin biopsy. He was diagnosed as relapse lymphoma, so 2 cycles of R-DHAP were given. There was no treatment response; therefore, R-ICE regimen was started. The patient had achieved second complete remission and his skin lesions were completely regressed. The involvement of skin with CD20+ cells after 7 cycles of rituximab therapy favors that there is a rituximab resistant disease which tends to involve the skin. To conclude, DLBCL may relapse extensively with cutaneous involvement and the best treatment option in these patients is salvage chemotherapy followed by autologous peripheral blood stem cell transplantation.
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spelling pubmed-45927112015-10-11 Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse Malkan, Umit Yavuz Gunes, Gursel Yayar, Okan Demiroglu, Haluk Case Rep Med Case Report Herein, we aimed to report a diffuse large B cell lymphoma (DLBCL) case that had extensive cutaneous relapse with no skin involvement previously. A 59-year-old man presented to hospital in April 2014 with fatigue, anorexia, fever, and anemia. Cervical lymph node biopsy revealed CD20+, BCL2+, MUM1+, BCL6+ high grade B lymphoproliferative neoplasm. After FISH investigation, he was diagnosed as DLBCL. He was given 7 cycles of R-CHOP and achieved remission. However, in November 2014, he had emerging skin lesions that cover nearly all of his body. A control PET-CT revealed diffuse cutaneous involvement. CD20+, BCL2+, MUM1+, BCL6+ high grade B cell lymphoma infiltration was detected with skin biopsy. He was diagnosed as relapse lymphoma, so 2 cycles of R-DHAP were given. There was no treatment response; therefore, R-ICE regimen was started. The patient had achieved second complete remission and his skin lesions were completely regressed. The involvement of skin with CD20+ cells after 7 cycles of rituximab therapy favors that there is a rituximab resistant disease which tends to involve the skin. To conclude, DLBCL may relapse extensively with cutaneous involvement and the best treatment option in these patients is salvage chemotherapy followed by autologous peripheral blood stem cell transplantation. Hindawi Publishing Corporation 2015 2015-09-20 /pmc/articles/PMC4592711/ /pubmed/26457084 http://dx.doi.org/10.1155/2015/137682 Text en Copyright © 2015 Umit Yavuz Malkan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Malkan, Umit Yavuz
Gunes, Gursel
Yayar, Okan
Demiroglu, Haluk
Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse
title Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse
title_full Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse
title_fullStr Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse
title_full_unstemmed Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse
title_short Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse
title_sort diffuse large b cell lymphoma with extensive cutaneous relapse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592711/
https://www.ncbi.nlm.nih.gov/pubmed/26457084
http://dx.doi.org/10.1155/2015/137682
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AT demirogluhaluk diffuselargebcelllymphomawithextensivecutaneousrelapse