Cargando…

Reactive Oxygen Species Donors Increase the Responsiveness of Dorsal Horn Neurons and Induce Mechanical Hyperalgesia in Rats

Our previous studies suggest that reactive oxygen species (ROS) scavengers have analgesic effect on neuropathic pain through spinal mechanisms in the rat. The studies suggest that superoxide in spinal cord is one of important mediators of persistent pain. To test the hypothesis that increase of supe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hee Young, Lee, Inhyung, Chun, Sang Woo, Kim, Hee Kee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592728/ https://www.ncbi.nlm.nih.gov/pubmed/26457204 http://dx.doi.org/10.1155/2015/293423

Ejemplares similares

Reactive oxygen species increase neuronal excitability via activation of nonspecific cation channel in rat medullary dorsal horn neurons
por: Lee, Hae In, et al.
Publicado: (2017)

Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia
por: Qi, Jian, et al.
Publicado: (2016)

Neuron Type-Dependent Synaptic Activity in the Spinal Dorsal Horn of Opioid-Induced Hyperalgesia Mouse Model
por: Kearns, Austin, et al.
Publicado: (2021)

Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons
por: Kopach, Olga, et al.
Publicado: (2012)

Electroacupuncture relieves hyperalgesia by regulating neuronal–glial interaction and glutamate transporters of spinal dorsal horns in rats with acute incisional neck pain
por: Wang, Jun-ying, et al.
Publicado: (2022)

The effect of µ-opioid receptor activation on GABAergic neurons in the spinal dorsal horn
por: Kim, Yoo Rim, et al.
Publicado: (2018)

Reduction in inhibitory control is sufficient to generate hyperalgesia in a spiking model of nociceptive integration in the superficial dorsal horn
por: Sousa, Mafalda, et al.
Publicado: (2013)

Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury
por: Mo, Cheng, et al.
Publicado: (2018)

The Contribution of TSLP Activation to Hyperalgesia in Dorsal Root Ganglia Neurons of a Rat
por: Lu, Chun-Ching, et al.
Publicado: (2022)

Expression of cholecystokinin by neurons in mouse spinal dorsal horn
por: Gutierrez‐Mecinas, Maria, et al.
Publicado: (2019)

Persistent At-Level Thermal Hyperalgesia and Tactile Allodynia Accompany Chronic Neuronal and Astrocyte Activation in Superficial Dorsal Horn following Mouse Cervical Contusion Spinal Cord Injury
por: Watson, Jaime L., et al.
Publicado: (2014)

Inhibition of dorsal raphe GABAergic neurons blocks hyperalgesia during heroin withdrawal
por: Alvarez-Bagnarol, Yocasta, et al.
Publicado: (2023)

Mitochondrial superoxide increases excitatory synaptic strength in spinal dorsal horn neurons of neuropathic mice
por: Bae, Chilman, et al.
Publicado: (2018)

Intraganglionic reactive oxygen species mediate inflammatory pain and hyperalgesia through TRPA1 in the rat
por: Zhang, Youping, et al.
Publicado: (2023)

Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model
por: Zhang, Enji, et al.
Publicado: (2015)

Origin and classification of spontaneous discharges in mouse superficial dorsal horn neurons
por: Lucas-Romero, Javier, et al.
Publicado: (2018)

Spinoparabrachial projection neurons form distinct classes in the mouse dorsal horn
por: Browne, Tyler J., et al.
Publicado: (2021)

Rolipram, a Selective Phosphodiesterase 4 Inhibitor, Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain through Inhibition of Inflammatory Cytokines in the Dorsal Root Ganglion
por: Kim, Hee Kee, et al.
Publicado: (2017)

Synchronous firing of dorsal horn neurons at the origin of dorsal root reflexes in naïve and paw-inflamed mice
por: Lucas-Romero, Javier, et al.
Publicado: (2022)

TWIK-Related Spinal Cord K(+) Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation
por: Hwang, Hee Youn, et al.
Publicado: (2015)

Defining populations of dorsal horn interneurons
por: Graham, Brett A., et al.
Publicado: (2020)

Inward currents induced by ischemia in rat spinal cord dorsal horn neurons
por: Chen, Meng, et al.
Publicado: (2007)

Pain-related synaptic plasticity in spinal dorsal horn neurons: role of CGRP
por: Bird, Gary C, et al.
Publicado: (2006)

Dynorphin is expressed primarily by GABAergic neurons that contain galanin in the rat dorsal horn
por: Sardella, Thomas CP, et al.
Publicado: (2011)

Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn
por: Punnakkal, Pradeep, et al.
Publicado: (2014)

Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn
por: Ohashi, Nobuko, et al.
Publicado: (2015)

Gabapentin prevents oxaliplatin-induced central sensitization in the dorsal horn neurons in rats
por: Ruyang, Teng, et al.
Publicado: (2015)

Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity
por: Alles, Sascha R. A., et al.
Publicado: (2021)

Differential Modulation of Dorsal Horn Neurons by Various Spinal Cord Stimulation Strategies
por: Lee, Kwan Yeop, et al.
Publicado: (2021)

Synaptic Targets of Glycinergic Neurons in Laminae I–III of the Spinal Dorsal Horn
por: Miranda, Camila Oliveira, et al.
Publicado: (2023)

Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord
por: Quillet, Raphaëlle, et al.
Publicado: (2023)

Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn
por: Lee, Kwan Yeop, et al.
Publicado: (2019)

Sensory neuron–derived Na(V)1.7 contributes to dorsal horn neuron excitability
por: Alles, Sascha R. A., et al.
Publicado: (2020)

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture
por: Hendrich, Janek, et al.
Publicado: (2012)

Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
por: Fan, Yu, et al.
Publicado: (2020)

Differential involvement of reactive oxygen species in a mouse model of capsaicin-induced secondary mechanical hyperalgesia and allodynia
por: La, Jun-Ho, et al.
Publicado: (2017)

Enhancement of spinal dorsal horn neuron N-methyl-D-aspartate receptor phosphorylation as the mechanism of remifentanil-induced hyperalgesia: Roles of protein kinase C and calcium/calmodulin-dependent protein kinase II
por: Li, Sisi, et al.
Publicado: (2017)

Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats
por: Gu, Wei, et al.
Publicado: (2017)

Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity
por: Pidoux, Ludivine, et al.
Publicado: (2022)

Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons
por: Georgiev, Stefan K, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_0agsgbark31fihnfmkfliqpdi9