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USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination

Ubiquitin modification of the TGF-β pathway components is emerging as a key mechanism of TGF-β pathway regulation. To limit TGF-β responses, TGF-β signaling is regulated through a negative feedback loop whereby the E3 ligase SMURF2 targets the TGF-β receptor (TβR) complex for ubiquitin-mediated degr...

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Detalles Bibliográficos
Autores principales:	Iyengar, Prasanna Vasudevan, Jaynes, Patrick, Rodon, Laura, Lama, Dilraj, Law, Kai Pong, Lim, Yoon Pin, Verma, Chandra, Seoane, Joan, Eichhorn, Pieter Johan Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593006/ https://www.ncbi.nlm.nih.gov/pubmed/26435193 http://dx.doi.org/10.1038/srep14733

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