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HDL particle number and size as predictors of cardiovascular disease
Previous studies indicate that reduced concentrations of circulating high-density lipoprotein (HDL) particles can be superior to HDL-cholesterol (HDL-C) levels as a predictor of cardiovascular disease. Measurements of HDL particle numbers, therefore, bear a potential for the improved assessment of c...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593254/ https://www.ncbi.nlm.nih.gov/pubmed/26500551 http://dx.doi.org/10.3389/fphar.2015.00218 |
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author | Kontush, Anatol |
author_facet | Kontush, Anatol |
author_sort | Kontush, Anatol |
collection | PubMed |
description | Previous studies indicate that reduced concentrations of circulating high-density lipoprotein (HDL) particles can be superior to HDL-cholesterol (HDL-C) levels as a predictor of cardiovascular disease. Measurements of HDL particle numbers, therefore, bear a potential for the improved assessment of cardiovascular risk. Furthermore, such measurement can be relevant for the evaluation of novel therapeutic approaches targeting HDL. Modern in-depth analyses of HDL particle profile may further improve evaluation of cardiovascular risk. Although clinical relevance of circulating concentrations of HDL subpopulations to cardiovascular disease remains controversial, the negative relationship between the number of large HDL particles and cardiovascular disease suggests that assessment of HDL particle profile can be clinically useful. Reduced mean HDL size is equally associated with cardiovascular disease in large-scale clinical studies. Since HDL-C is primarily carried in the circulation by large, lipid-rich HDL particles, the inverse relationship between HDL size and cardiovascular risk can be secondary to those established for plasma levels of HDL particles, HDL-C, and large HDL. The epidemiological data thereby suggest that HDL particle number may represent a more relevant therapeutic target as compared to HDL-C. |
format | Online Article Text |
id | pubmed-4593254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45932542015-10-23 HDL particle number and size as predictors of cardiovascular disease Kontush, Anatol Front Pharmacol Pharmacology Previous studies indicate that reduced concentrations of circulating high-density lipoprotein (HDL) particles can be superior to HDL-cholesterol (HDL-C) levels as a predictor of cardiovascular disease. Measurements of HDL particle numbers, therefore, bear a potential for the improved assessment of cardiovascular risk. Furthermore, such measurement can be relevant for the evaluation of novel therapeutic approaches targeting HDL. Modern in-depth analyses of HDL particle profile may further improve evaluation of cardiovascular risk. Although clinical relevance of circulating concentrations of HDL subpopulations to cardiovascular disease remains controversial, the negative relationship between the number of large HDL particles and cardiovascular disease suggests that assessment of HDL particle profile can be clinically useful. Reduced mean HDL size is equally associated with cardiovascular disease in large-scale clinical studies. Since HDL-C is primarily carried in the circulation by large, lipid-rich HDL particles, the inverse relationship between HDL size and cardiovascular risk can be secondary to those established for plasma levels of HDL particles, HDL-C, and large HDL. The epidemiological data thereby suggest that HDL particle number may represent a more relevant therapeutic target as compared to HDL-C. Frontiers Media S.A. 2015-10-05 /pmc/articles/PMC4593254/ /pubmed/26500551 http://dx.doi.org/10.3389/fphar.2015.00218 Text en Copyright © 2015 Kontush. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Kontush, Anatol HDL particle number and size as predictors of cardiovascular disease |
title | HDL particle number and size as predictors of cardiovascular disease |
title_full | HDL particle number and size as predictors of cardiovascular disease |
title_fullStr | HDL particle number and size as predictors of cardiovascular disease |
title_full_unstemmed | HDL particle number and size as predictors of cardiovascular disease |
title_short | HDL particle number and size as predictors of cardiovascular disease |
title_sort | hdl particle number and size as predictors of cardiovascular disease |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593254/ https://www.ncbi.nlm.nih.gov/pubmed/26500551 http://dx.doi.org/10.3389/fphar.2015.00218 |
work_keys_str_mv | AT kontushanatol hdlparticlenumberandsizeaspredictorsofcardiovasculardisease |