Wnt3a: functions and implications in cancer

Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depend...

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Detalles Bibliográficos
Autores principales: He, Sha, Lu, Yi, Liu, Xia, Huang, Xin, Keller, Evan T., Qian, Chao-Nan, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593336/
https://www.ncbi.nlm.nih.gov/pubmed/26369691
http://dx.doi.org/10.1186/s40880-015-0052-4
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author He, Sha
Lu, Yi
Liu, Xia
Huang, Xin
Keller, Evan T.
Qian, Chao-Nan
Zhang, Jian
author_facet He, Sha
Lu, Yi
Liu, Xia
Huang, Xin
Keller, Evan T.
Qian, Chao-Nan
Zhang, Jian
author_sort He, Sha
collection PubMed
description Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.
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spelling pubmed-45933362015-10-06 Wnt3a: functions and implications in cancer He, Sha Lu, Yi Liu, Xia Huang, Xin Keller, Evan T. Qian, Chao-Nan Zhang, Jian Chin J Cancer Review Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer. BioMed Central 2015-09-14 /pmc/articles/PMC4593336/ /pubmed/26369691 http://dx.doi.org/10.1186/s40880-015-0052-4 Text en © He et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
He, Sha
Lu, Yi
Liu, Xia
Huang, Xin
Keller, Evan T.
Qian, Chao-Nan
Zhang, Jian
Wnt3a: functions and implications in cancer
title Wnt3a: functions and implications in cancer
title_full Wnt3a: functions and implications in cancer
title_fullStr Wnt3a: functions and implications in cancer
title_full_unstemmed Wnt3a: functions and implications in cancer
title_short Wnt3a: functions and implications in cancer
title_sort wnt3a: functions and implications in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593336/
https://www.ncbi.nlm.nih.gov/pubmed/26369691
http://dx.doi.org/10.1186/s40880-015-0052-4
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