Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins

Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferatio...

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Detalles Bibliográficos
Autores principales: Zeng, Meiqi, Zheng, Manyin, Lu, Desheng, Wang, Jun, Jiang, Wenqi, Sha, Ou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593346/
https://www.ncbi.nlm.nih.gov/pubmed/26184404
http://dx.doi.org/10.1186/s40880-015-0030-x
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author Zeng, Meiqi
Zheng, Manyin
Lu, Desheng
Wang, Jun
Jiang, Wenqi
Sha, Ou
author_facet Zeng, Meiqi
Zheng, Manyin
Lu, Desheng
Wang, Jun
Jiang, Wenqi
Sha, Ou
author_sort Zeng, Meiqi
collection PubMed
description Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
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spelling pubmed-45933462015-10-06 Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins Zeng, Meiqi Zheng, Manyin Lu, Desheng Wang, Jun Jiang, Wenqi Sha, Ou Chin J Cancer Review Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways. BioMed Central 2015-07-17 /pmc/articles/PMC4593346/ /pubmed/26184404 http://dx.doi.org/10.1186/s40880-015-0030-x Text en © Zeng et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zeng, Meiqi
Zheng, Manyin
Lu, Desheng
Wang, Jun
Jiang, Wenqi
Sha, Ou
Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
title Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
title_full Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
title_fullStr Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
title_full_unstemmed Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
title_short Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
title_sort anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593346/
https://www.ncbi.nlm.nih.gov/pubmed/26184404
http://dx.doi.org/10.1186/s40880-015-0030-x
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