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Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010
In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as ser...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593426/ https://www.ncbi.nlm.nih.gov/pubmed/26401714 http://dx.doi.org/10.3201/eid2110.141660 |
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author | Auguste, Albert J. Liria, Jonathan Forrester, Naomi L. Giambalvo, Dileyvic Moncada, Maria Long, Kanya C. Morón, Dulce de Manzione, Nuris Tesh, Robert B. Halsey, Eric S. Kochel, Tadeusz J. Hernandez, Rosa Navarro, Juan-Carlos Weaver, Scott C. |
author_facet | Auguste, Albert J. Liria, Jonathan Forrester, Naomi L. Giambalvo, Dileyvic Moncada, Maria Long, Kanya C. Morón, Dulce de Manzione, Nuris Tesh, Robert B. Halsey, Eric S. Kochel, Tadeusz J. Hernandez, Rosa Navarro, Juan-Carlos Weaver, Scott C. |
author_sort | Auguste, Albert J. |
collection | PubMed |
description | In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acute-phase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions. |
format | Online Article Text |
id | pubmed-4593426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-45934262015-10-05 Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010 Auguste, Albert J. Liria, Jonathan Forrester, Naomi L. Giambalvo, Dileyvic Moncada, Maria Long, Kanya C. Morón, Dulce de Manzione, Nuris Tesh, Robert B. Halsey, Eric S. Kochel, Tadeusz J. Hernandez, Rosa Navarro, Juan-Carlos Weaver, Scott C. Emerg Infect Dis Research In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acute-phase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions. Centers for Disease Control and Prevention 2015-10 /pmc/articles/PMC4593426/ /pubmed/26401714 http://dx.doi.org/10.3201/eid2110.141660 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Auguste, Albert J. Liria, Jonathan Forrester, Naomi L. Giambalvo, Dileyvic Moncada, Maria Long, Kanya C. Morón, Dulce de Manzione, Nuris Tesh, Robert B. Halsey, Eric S. Kochel, Tadeusz J. Hernandez, Rosa Navarro, Juan-Carlos Weaver, Scott C. Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010 |
title | Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010 |
title_full | Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010 |
title_fullStr | Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010 |
title_full_unstemmed | Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010 |
title_short | Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010 |
title_sort | evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, venezuela, 2010 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593426/ https://www.ncbi.nlm.nih.gov/pubmed/26401714 http://dx.doi.org/10.3201/eid2110.141660 |
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