Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain

In late 2013, the largest documented outbreak of Ebola hemorrhagic fever started in Guinea and has since spread to neighboring countries, resulting in almost 27,000 cases and >11,000 deaths in humans. In March 2014, Ebola virus (EBOV) was identified as the causative agent. This study compares the...

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Autores principales: Marzi, Andrea, Feldmann, Friederike, Hanley, Patrick W., Scott, Dana P., Günther, Stephan, Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593438/
https://www.ncbi.nlm.nih.gov/pubmed/26402165
http://dx.doi.org/10.3201/eid2110.150259
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author Marzi, Andrea
Feldmann, Friederike
Hanley, Patrick W.
Scott, Dana P.
Günther, Stephan
Feldmann, Heinz
author_facet Marzi, Andrea
Feldmann, Friederike
Hanley, Patrick W.
Scott, Dana P.
Günther, Stephan
Feldmann, Heinz
author_sort Marzi, Andrea
collection PubMed
description In late 2013, the largest documented outbreak of Ebola hemorrhagic fever started in Guinea and has since spread to neighboring countries, resulting in almost 27,000 cases and >11,000 deaths in humans. In March 2014, Ebola virus (EBOV) was identified as the causative agent. This study compares the pathogenesis of a new EBOV strain, Makona, which was isolated in Guinea in 2014 with the prototype strain from the 1976 EBOV outbreak in the former Zaire. Both strains cause lethal disease in cynomolgus macaques with similar pathologic changes and hallmark features of Ebola hemorrhagic fever. However, disease progression was delayed in EBOV-Makona–infected animals, suggesting decreased rather than increased virulence of this most recent EBOV strain.
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spelling pubmed-45934382015-10-05 Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain Marzi, Andrea Feldmann, Friederike Hanley, Patrick W. Scott, Dana P. Günther, Stephan Feldmann, Heinz Emerg Infect Dis Research In late 2013, the largest documented outbreak of Ebola hemorrhagic fever started in Guinea and has since spread to neighboring countries, resulting in almost 27,000 cases and >11,000 deaths in humans. In March 2014, Ebola virus (EBOV) was identified as the causative agent. This study compares the pathogenesis of a new EBOV strain, Makona, which was isolated in Guinea in 2014 with the prototype strain from the 1976 EBOV outbreak in the former Zaire. Both strains cause lethal disease in cynomolgus macaques with similar pathologic changes and hallmark features of Ebola hemorrhagic fever. However, disease progression was delayed in EBOV-Makona–infected animals, suggesting decreased rather than increased virulence of this most recent EBOV strain. Centers for Disease Control and Prevention 2015-10 /pmc/articles/PMC4593438/ /pubmed/26402165 http://dx.doi.org/10.3201/eid2110.150259 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Marzi, Andrea
Feldmann, Friederike
Hanley, Patrick W.
Scott, Dana P.
Günther, Stephan
Feldmann, Heinz
Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain
title Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain
title_full Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain
title_fullStr Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain
title_full_unstemmed Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain
title_short Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain
title_sort delayed disease progression in cynomolgus macaques infected with ebola virus makona strain
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593438/
https://www.ncbi.nlm.nih.gov/pubmed/26402165
http://dx.doi.org/10.3201/eid2110.150259
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