Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014

We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The repro...

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Detalles Bibliográficos
Autores principales: Lindblade, Kim A., Kateh, Francis, Nagbe, Thomas K., Neatherlin, John C., Pillai, Satish K., Attfield, Kathleen R., Dweh, Emmanuel, Barradas, Danielle T., Williams, Seymour G., Blackley, David J., Kirking, Hannah L., Patel, Monita R., Dea, Monica, Massoudi, Mehran S., Wannemuehler, Kathleen, Barskey, Albert E., Zarecki, Shauna L. Mettee, Fomba, Moses, Grube, Steven, Belcher, Lisa, Broyles, Laura N., Maxwell, T. Nikki, Hagan, Jose E., Yeoman, Kristin, Westercamp, Matthew, Forrester, Joseph, Mott, Joshua, Mahoney, Frank, Slutsker, Laurence, DeCock, Kevin M., Nyenswah, Tolbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593457/
https://www.ncbi.nlm.nih.gov/pubmed/26402477
http://dx.doi.org/10.3201/eid2110.150912
Descripción
Sumario:We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1–2.6) to 0.1 (95% CI 0.02–0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04–0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60–74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4–0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.

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