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Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling

Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2. We assessed whether blockade of mineralocorticoid receptors (MR) with spironolactone decreases reactive...

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Detalles Bibliográficos
Autores principales:	Silva, Marcondes A. B., Bruder-Nascimento, Thiago, Cau, Stefany B. A., Lopes, Rheure A. M., Mestriner, Fabiola L. A. C., Fais, Rafael S., Touyz, Rhian M., Tostes, Rita C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593519/ https://www.ncbi.nlm.nih.gov/pubmed/26500555 http://dx.doi.org/10.3389/fphys.2015.00269

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