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Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2
Insulin is secreted from the pancreatic β-cells in response to elevated glucose. In intact islets the capacity for insulin release is determined by a complex interplay between different cell types. This has made it difficult to specifically assess the role of β-cell defects to the insulin secretory...
Autores principales: | Reinbothe, Thomas M, Safi, Fatemeh, Axelsson, Annika S, Mollet, Inês G, Rosengren, Anders H |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593566/ https://www.ncbi.nlm.nih.gov/pubmed/25483880 http://dx.doi.org/10.4161/isl.28095 |
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