SubClonal Hierarchy Inference from Somatic Mutations: Automatic Reconstruction of Cancer Evolutionary Trees from Multi-region Next Generation Sequencing

Recent improvements in next-generation sequencing of tumor samples and the ability to identify somatic mutations at low allelic fractions have opened the way for new approaches to model the evolution of individual cancers. The power and utility of these models is increased when tumor samples from mu...

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Detalles Bibliográficos
Autores principales: Niknafs, Noushin, Beleva-Guthrie, Violeta, Naiman, Daniel Q., Karchin, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593588/
https://www.ncbi.nlm.nih.gov/pubmed/26436540
http://dx.doi.org/10.1371/journal.pcbi.1004416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593588/
https://www.ncbi.nlm.nih.gov/pubmed/26436540
http://dx.doi.org/10.1371/journal.pcbi.1004416

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