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Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly and is characterized by memory loss and cognitive decline. Pathological hallmark of AD brains are intracellular neurofibrillary tangles and extracellular amyloid plaques. The major component of these plaques is the highly heter...

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Detalles Bibliográficos
Autores principales:	Dammers, Christina, Gremer, Lothar, Neudecker, Philipp, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593648/ https://www.ncbi.nlm.nih.gov/pubmed/26436664 http://dx.doi.org/10.1371/journal.pone.0139710

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