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Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593667/ https://www.ncbi.nlm.nih.gov/pubmed/26333836 http://dx.doi.org/10.1098/rsob.150093 |
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author | Sanchez-Alvarez, Miguel Zhang, Qifeng Finger, Fabian Wakelam, Michael J. O. Bakal, Chris |
author_facet | Sanchez-Alvarez, Miguel Zhang, Qifeng Finger, Fabian Wakelam, Michael J. O. Bakal, Chris |
author_sort | Sanchez-Alvarez, Miguel |
collection | PubMed |
description | We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. |
format | Online Article Text |
id | pubmed-4593667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-45936672015-10-15 Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis Sanchez-Alvarez, Miguel Zhang, Qifeng Finger, Fabian Wakelam, Michael J. O. Bakal, Chris Open Biol Research We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. The Royal Society 2015-09-02 /pmc/articles/PMC4593667/ /pubmed/26333836 http://dx.doi.org/10.1098/rsob.150093 Text en © 2015 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Research Sanchez-Alvarez, Miguel Zhang, Qifeng Finger, Fabian Wakelam, Michael J. O. Bakal, Chris Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis |
title | Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis |
title_full | Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis |
title_fullStr | Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis |
title_full_unstemmed | Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis |
title_short | Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis |
title_sort | cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593667/ https://www.ncbi.nlm.nih.gov/pubmed/26333836 http://dx.doi.org/10.1098/rsob.150093 |
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