Cargando…

Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis

We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell p...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanchez-Alvarez, Miguel, Zhang, Qifeng, Finger, Fabian, Wakelam, Michael J. O., Bakal, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593667/
https://www.ncbi.nlm.nih.gov/pubmed/26333836
http://dx.doi.org/10.1098/rsob.150093
_version_ 1782393357797949440
author Sanchez-Alvarez, Miguel
Zhang, Qifeng
Finger, Fabian
Wakelam, Michael J. O.
Bakal, Chris
author_facet Sanchez-Alvarez, Miguel
Zhang, Qifeng
Finger, Fabian
Wakelam, Michael J. O.
Bakal, Chris
author_sort Sanchez-Alvarez, Miguel
collection PubMed
description We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth.
format Online
Article
Text
id pubmed-4593667
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-45936672015-10-15 Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis Sanchez-Alvarez, Miguel Zhang, Qifeng Finger, Fabian Wakelam, Michael J. O. Bakal, Chris Open Biol Research We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. The Royal Society 2015-09-02 /pmc/articles/PMC4593667/ /pubmed/26333836 http://dx.doi.org/10.1098/rsob.150093 Text en © 2015 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Research
Sanchez-Alvarez, Miguel
Zhang, Qifeng
Finger, Fabian
Wakelam, Michael J. O.
Bakal, Chris
Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
title Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
title_full Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
title_fullStr Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
title_full_unstemmed Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
title_short Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
title_sort cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593667/
https://www.ncbi.nlm.nih.gov/pubmed/26333836
http://dx.doi.org/10.1098/rsob.150093
work_keys_str_mv AT sanchezalvarezmiguel cellcycleprogressionisanessentialregulatorycomponentofphospholipidmetabolismandmembranehomeostasis
AT zhangqifeng cellcycleprogressionisanessentialregulatorycomponentofphospholipidmetabolismandmembranehomeostasis
AT fingerfabian cellcycleprogressionisanessentialregulatorycomponentofphospholipidmetabolismandmembranehomeostasis
AT wakelammichaeljo cellcycleprogressionisanessentialregulatorycomponentofphospholipidmetabolismandmembranehomeostasis
AT bakalchris cellcycleprogressionisanessentialregulatorycomponentofphospholipidmetabolismandmembranehomeostasis