Cargando…

Bifunctional crosslinking ligands for transthyretin

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mangione, P. Patrizia, Deroo, Stéphanie, Ellmerich, Stephan, Bellotti, Vittorio, Kolstoe, Simon, Wood, Stephen P., Robinson, Carol V., Smith, Martin D., Tennent, Glenys A., Broadbridge, Robert J., Council, Claire E., Thurston, Joanne R., Steadman, Victoria A., Vong, Antonio K., Swain, Christopher J., Pepys, Mark B., Taylor, Graham W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593668/ https://www.ncbi.nlm.nih.gov/pubmed/26400472 http://dx.doi.org/10.1098/rsob.150105

Ejemplares similares

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis
por: Slamova, Ivana, et al.
Publicado: (2021)

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes
por: Corazza, Alessandra, et al.
Publicado: (2019)

Calcium Binds to Transthyretin with Low Affinity
por: Cantarutti, Cristina, et al.
Publicado: (2022)

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel
por: Verona, Guglielmo, et al.
Publicado: (2017)

Plasminogen activation triggers transthyretin amyloidogenesis in vitro
por: Mangione, P. Patrizia, et al.
Publicado: (2018)

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
por: Marcoux, Julien, et al.
Publicado: (2015)

Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
por: Bodin, Karl, et al.
Publicado: (2010)

Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C‐reactive protein, for clinical use
por: Pepys, Mark B., et al.
Publicado: (2012)

C-reactive protein is essential for innate resistance to pneumococcal infection
por: Paul Simons, J, et al.
Publicado: (2014)

Letter: Induction of tumours and bifunctional crosslinking metabolites of nitrosamines.
por: Schoental, R.
Publicado: (1976)

Crosslinked Bifunctional Particles for the Removal of Bilirubin in Hyperbilirubinemia Cases
por: Garrido, María del Prado, et al.
Publicado: (2023)

A Narrative Review of the Role of Transthyretin in Health and Disease
por: Liz, Marcia Almeida, et al.
Publicado: (2020)

Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction
por: Milde, Ronny, et al.
Publicado: (2015)

Bifunctional Non-Canonical Amino Acids: Combining Photo-Crosslinking with Click Chemistry †
por: Hoffmann, Jan-Erik
Publicado: (2020)

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo
por: Al-Shawi, Raya, et al.
Publicado: (2016)

Interaction of serum amyloid P component with hexanoyl bis(d-proline) (CPHPC)
por: Kolstoe, Simon E., et al.
Publicado: (2014)

Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro
por: Ozawa, Daisaku, et al.
Publicado: (2016)

Amyloid persistence in decellularized liver: biochemical and histopathological characterization
por: Mazza, Giuseppe, et al.
Publicado: (2016)

Modeling of Survival and Frequency of Cardiovascular-Related Hospitalization in Patients with Transthyretin Amyloid Cardiomyopathy Treated with Tafamidis
por: Vong, Camille, et al.
Publicado: (2021)

Genetic evidence for serum amyloid P component as a drug target for treatment of neurodegenerative disorders
por: Schmidt, A Floriaan, et al.
Publicado: (2023)

Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies
por: Mangione, P. Patrizia, et al.
Publicado: (2017)

A Common β-Sheet Architecture Underlies in Vitro and in Vivo β(2)-Microglobulin Amyloid Fibrils
por: Jahn, Thomas R., et al.
Publicado: (2008)

EGCG-Mediated Protection of Transthyretin Amyloidosis by Stabilizing Transthyretin Tetramers and Disrupting Transthyretin Aggregates
por: Zou, Huizhen, et al.
Publicado: (2023)

Transthyretin Stabilizers and Seeding Inhibitors as Therapies for Amyloid Transthyretin Cardiomyopathy
por: Morfino, Paolo, et al.
Publicado: (2023)

Extracellular Vesicles Contribute to the Metabolism of Transthyretin Amyloid in Hereditary Transthyretin Amyloidosis
por: Yamaguchi, Hiroki, et al.
Publicado: (2022)

Frequency of hereditary transthyretin amyloidosis among elderly patients with transthyretin cardiomyopathy
por: Maestro‐Benedicto, Alba, et al.
Publicado: (2022)

Transthyretin cardiac amyloidosis
por: Tomoaia, Raluca, et al.
Publicado: (2021)

Transthyretin cardiac amyloidosis
por: Porcari, Aldostefano, et al.
Publicado: (2022)

Bifunctional catalysis
por: Dixon, Darren J
Publicado: (2016)

Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?
por: Li, Xinyi, et al.
Publicado: (2011)

The Importance of a Gatekeeper Residue on the Aggregation of Transthyretin: IMPLICATIONS FOR TRANSTHYRETIN-RELATED AMYLOIDOSES
por: Sant'Anna, Ricardo, et al.
Publicado: (2014)

Effects of Tafamidis on Transthyretin Stabilization and Clinical Outcomes in Patients with Non-Val30Met Transthyretin Amyloidosis
por: Merlini, Giampaolo, et al.
Publicado: (2013)

C. elegans Expressing Human β(2)-Microglobulin: A Novel Model for Studying the Relationship between the Molecular Assembly and the Toxic Phenotype
por: Diomede, Luisa, et al.
Publicado: (2012)

A molecular mechanism for transthyretin amyloidogenesis
por: Yee, Ai Woon, et al.
Publicado: (2019)

Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein
por: Moura, Alexandra, et al.
Publicado: (2020)

Structure, Folding Dynamics, and Amyloidogenesis of D76N β(2)-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN
por: Mangione, P. Patrizia, et al.
Publicado: (2013)

Temporal Trends of Wild-Type Transthyretin Amyloid Cardiomyopathy in the Transthyretin Amyloidosis Outcomes Survey
por: Nativi-Nicolau, Jose, et al.
Publicado: (2021)

Effect of Tafamidis on Serum Transthyretin Levels in Non-Trial Patients With Transthyretin Amyloid Cardiomyopathy
por: Falk, Rodney H., et al.
Publicado: (2021)

Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function
por: Nakano, Tomoya, et al.
Publicado: (2022)

Spectrum of transthyretin gene mutations and clinical characteristics of Polish patients with cardiac transthyretin amyloidosis
por: Gawor, Monika, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_no0s3orgesr8q9g512tq6tt2k0