IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin damage from the nucleus back to the surrounding tissue through the cytokine interleukin-1alpha (IL-1α). Thus, in addition to its role as a dange...

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Detalles Bibliográficos
Autores principales: Idan, Cohen, Peleg, Rider, Elena, Voronov, Martin, Tomas, Cicerone, Tudor, Mareike, Wegner, Lydia, Brondani, Marina, Freudenberg, Gerhard, Mittler, Elisa, Ferrando-May, Dinarello, Charles A., Ron, Apte N., Robert, Schneider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593953/
https://www.ncbi.nlm.nih.gov/pubmed/26439902
http://dx.doi.org/10.1038/srep14756

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