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IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

CD4(+)FOXP3(+) regulatory T (Treg) cells are essential for maintaining immunological self-tolerance. Treg cell development and function depend on the transcription factor FOXP3, which is present in several distinct isoforms due to alternative splicing. Despite the importance of FOXP3 in the proper m...

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Detalles Bibliográficos
Autores principales:	Mailer, Reiner K. W., Joly, Anne-Laure, Liu, Sang, Elias, Szabolcs, Tegner, Jesper, Andersson, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593960/ https://www.ncbi.nlm.nih.gov/pubmed/26441347 http://dx.doi.org/10.1038/srep14674

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