A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion

The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has implicated Rab5 as a critical regulator of cell adhesion, migration and invasion in both normal and tumor cells. These recent findings showing that Rab5 promotes Rac...

Descripción completa

Detalles Bibliográficos
Autores principales: Díaz, Jorge, Mendoza, Pablo, Silva, Patricio, Quest, Andrew FG, Torres, Vicente A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Article Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594484/
https://www.ncbi.nlm.nih.gov/pubmed/26842651
http://dx.doi.org/10.4161/19420889.2014.972850
_version_ 1782393458060689408
author Díaz, Jorge
Mendoza, Pablo
Silva, Patricio
Quest, Andrew FG
Torres, Vicente A
author_facet Díaz, Jorge
Mendoza, Pablo
Silva, Patricio
Quest, Andrew FG
Torres, Vicente A
author_sort Díaz, Jorge
collection PubMed
description The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has implicated Rab5 as a critical regulator of cell adhesion, migration and invasion in both normal and tumor cells. These recent findings showing that Rab5 promotes Rac1 activation and focal adhesion dynamics have highlighted the question as to what the upstream regulators of Rab5 activity might be and how these are connected to cell migration. The efforts to shed light on this issue identified in metastatic cancer cells a novel Caveolin‑1/p85α/Rab5/Tiam1/Rac1 signaling axis relevant to cancer cell migration and invasion. In this addendum, we highlight aspects concerning Rab5 regulation in this context.
format Online
Article
Text
id pubmed-4594484
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-45944842016-02-03 A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion Díaz, Jorge Mendoza, Pablo Silva, Patricio Quest, Andrew FG Torres, Vicente A Commun Integr Biol Article Addendum The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has implicated Rab5 as a critical regulator of cell adhesion, migration and invasion in both normal and tumor cells. These recent findings showing that Rab5 promotes Rac1 activation and focal adhesion dynamics have highlighted the question as to what the upstream regulators of Rab5 activity might be and how these are connected to cell migration. The efforts to shed light on this issue identified in metastatic cancer cells a novel Caveolin‑1/p85α/Rab5/Tiam1/Rac1 signaling axis relevant to cancer cell migration and invasion. In this addendum, we highlight aspects concerning Rab5 regulation in this context. Taylor & Francis 2014-10-30 /pmc/articles/PMC4594484/ /pubmed/26842651 http://dx.doi.org/10.4161/19420889.2014.972850 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Article Addendum
Díaz, Jorge
Mendoza, Pablo
Silva, Patricio
Quest, Andrew FG
Torres, Vicente A
A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
title A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
title_full A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
title_fullStr A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
title_full_unstemmed A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
title_short A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
title_sort novel caveolin-1/p85α/rab5/tiam1/rac1 signaling axis in tumor cell migration and invasion
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594484/
https://www.ncbi.nlm.nih.gov/pubmed/26842651
http://dx.doi.org/10.4161/19420889.2014.972850
work_keys_str_mv AT diazjorge anovelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT mendozapablo anovelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT silvapatricio anovelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT questandrewfg anovelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT torresvicentea anovelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT diazjorge novelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT mendozapablo novelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT silvapatricio novelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT questandrewfg novelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion
AT torresvicentea novelcaveolin1p85arab5tiam1rac1signalingaxisintumorcellmigrationandinvasion

Ejemplares similares