The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in contr...

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Autores principales: Wie, Jinhong, Kim, Byung Joo, Myeong, Jongyun, Ha, Kotdaji, Jeong, Seung Joo, Yang, Dongki, Kim, Euiyong, Jeon, Ju-Hong, So, Insuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594510/
https://www.ncbi.nlm.nih.gov/pubmed/26083271
http://dx.doi.org/10.1080/19336950.2015.1058454
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author Wie, Jinhong
Kim, Byung Joo
Myeong, Jongyun
Ha, Kotdaji
Jeong, Seung Joo
Yang, Dongki
Kim, Euiyong
Jeon, Ju-Hong
So, Insuk
author_facet Wie, Jinhong
Kim, Byung Joo
Myeong, Jongyun
Ha, Kotdaji
Jeong, Seung Joo
Yang, Dongki
Kim, Euiyong
Jeon, Ju-Hong
So, Insuk
author_sort Wie, Jinhong
collection PubMed
description TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gα(i/o) and Gα(q) protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.
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spelling pubmed-45945102016-02-03 The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels Wie, Jinhong Kim, Byung Joo Myeong, Jongyun Ha, Kotdaji Jeong, Seung Joo Yang, Dongki Kim, Euiyong Jeon, Ju-Hong So, Insuk Channels (Austin) Reviews TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gα(i/o) and Gα(q) protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling. Taylor & Francis 2015-06-17 /pmc/articles/PMC4594510/ /pubmed/26083271 http://dx.doi.org/10.1080/19336950.2015.1058454 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Reviews
Wie, Jinhong
Kim, Byung Joo
Myeong, Jongyun
Ha, Kotdaji
Jeong, Seung Joo
Yang, Dongki
Kim, Euiyong
Jeon, Ju-Hong
So, Insuk
The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
title The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
title_full The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
title_fullStr The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
title_full_unstemmed The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
title_short The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
title_sort roles of rasd1 small g proteins and leptin in the activation of trpc4 transient receptor potential channels
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594510/
https://www.ncbi.nlm.nih.gov/pubmed/26083271
http://dx.doi.org/10.1080/19336950.2015.1058454
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