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zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila

We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during patterning of the dorsal-ventral (D/V) axis in D. melanogaster embryos. We went on to show that other wild-type Drosophila species lack this...

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Detalles Bibliográficos
Autores principales: Gavin-Smyth, Jackie, Ferguson, Edwin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594538/
https://www.ncbi.nlm.nih.gov/pubmed/25482877
http://dx.doi.org/10.4161/19336934.2014.983385
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author Gavin-Smyth, Jackie
Ferguson, Edwin L
author_facet Gavin-Smyth, Jackie
Ferguson, Edwin L
author_sort Gavin-Smyth, Jackie
collection PubMed
description We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during patterning of the dorsal-ventral (D/V) axis in D. melanogaster embryos. We went on to show that other wild-type Drosophila species lack this canalizing genetic circuitry and, consequently, have non-robust D/V patterning. In this review, we propose molecular mechanisms that may give rise to stereotyped BMP signaling, and we identify an additional species that could have decanalized D/V patterning. Extension of these analyses could in turn help explain why canalization is not a universal necessity for species survival.
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spelling pubmed-45945382015-12-07 zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila Gavin-Smyth, Jackie Ferguson, Edwin L Fly (Austin) Extra Views We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during patterning of the dorsal-ventral (D/V) axis in D. melanogaster embryos. We went on to show that other wild-type Drosophila species lack this canalizing genetic circuitry and, consequently, have non-robust D/V patterning. In this review, we propose molecular mechanisms that may give rise to stereotyped BMP signaling, and we identify an additional species that could have decanalized D/V patterning. Extension of these analyses could in turn help explain why canalization is not a universal necessity for species survival. Taylor & Francis 2014-12-07 /pmc/articles/PMC4594538/ /pubmed/25482877 http://dx.doi.org/10.4161/19336934.2014.983385 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Extra Views
Gavin-Smyth, Jackie
Ferguson, Edwin L
zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila
title zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila
title_full zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila
title_fullStr zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila
title_full_unstemmed zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila
title_short zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila
title_sort zen and the art of phenotypic maintenance: canalization of embryonic dorsal-ventral patterning in drosophila
topic Extra Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594538/
https://www.ncbi.nlm.nih.gov/pubmed/25482877
http://dx.doi.org/10.4161/19336934.2014.983385
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