Cargando…
zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila
We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during patterning of the dorsal-ventral (D/V) axis in D. melanogaster embryos. We went on to show that other wild-type Drosophila species lack this...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594538/ https://www.ncbi.nlm.nih.gov/pubmed/25482877 http://dx.doi.org/10.4161/19336934.2014.983385 |
_version_ | 1782393463785914368 |
---|---|
author | Gavin-Smyth, Jackie Ferguson, Edwin L |
author_facet | Gavin-Smyth, Jackie Ferguson, Edwin L |
author_sort | Gavin-Smyth, Jackie |
collection | PubMed |
description | We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during patterning of the dorsal-ventral (D/V) axis in D. melanogaster embryos. We went on to show that other wild-type Drosophila species lack this canalizing genetic circuitry and, consequently, have non-robust D/V patterning. In this review, we propose molecular mechanisms that may give rise to stereotyped BMP signaling, and we identify an additional species that could have decanalized D/V patterning. Extension of these analyses could in turn help explain why canalization is not a universal necessity for species survival. |
format | Online Article Text |
id | pubmed-4594538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-45945382015-12-07 zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila Gavin-Smyth, Jackie Ferguson, Edwin L Fly (Austin) Extra Views We recently uncovered a novel genetic mechanism that generates the phenotypic uniformity, or canalization, of BMP signaling and cell fate specification during patterning of the dorsal-ventral (D/V) axis in D. melanogaster embryos. We went on to show that other wild-type Drosophila species lack this canalizing genetic circuitry and, consequently, have non-robust D/V patterning. In this review, we propose molecular mechanisms that may give rise to stereotyped BMP signaling, and we identify an additional species that could have decanalized D/V patterning. Extension of these analyses could in turn help explain why canalization is not a universal necessity for species survival. Taylor & Francis 2014-12-07 /pmc/articles/PMC4594538/ /pubmed/25482877 http://dx.doi.org/10.4161/19336934.2014.983385 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Extra Views Gavin-Smyth, Jackie Ferguson, Edwin L zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila |
title | zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila |
title_full | zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila |
title_fullStr | zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila |
title_full_unstemmed | zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila |
title_short | zen and the art of phenotypic maintenance: Canalization of embryonic dorsal-ventral patterning in Drosophila |
title_sort | zen and the art of phenotypic maintenance: canalization of embryonic dorsal-ventral patterning in drosophila |
topic | Extra Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594538/ https://www.ncbi.nlm.nih.gov/pubmed/25482877 http://dx.doi.org/10.4161/19336934.2014.983385 |
work_keys_str_mv | AT gavinsmythjackie zenandtheartofphenotypicmaintenancecanalizationofembryonicdorsalventralpatterningindrosophila AT fergusonedwinl zenandtheartofphenotypicmaintenancecanalizationofembryonicdorsalventralpatterningindrosophila |