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Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies

The p.I141V mutation of the voltage-gated sodium channel is associated with several clinical hyper-excitability phenotypes. To understand the structural bases of the p.I141V biophysical alterations, molecular dynamics simulations were performed. These simulations predicted that the p.I141V substitut...

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Detalles Bibliográficos
Autores principales:	Amarouch, Mohamed-Yassine, Kasimova, Marina A, Tarek, Mounir, Abriel, Hugues
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594541/ https://www.ncbi.nlm.nih.gov/pubmed/25483584 http://dx.doi.org/10.4161/19336950.2014.958922

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