The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila

Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila...

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Autores principales: Mirth, Christen Kerry, Shingleton, Alexander William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Article Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594587/
https://www.ncbi.nlm.nih.gov/pubmed/26842847
http://dx.doi.org/10.4161/cib.29240
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author Mirth, Christen Kerry
Shingleton, Alexander William
author_facet Mirth, Christen Kerry
Shingleton, Alexander William
author_sort Mirth, Christen Kerry
collection PubMed
description Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size.
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spelling pubmed-45945872016-02-03 The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila Mirth, Christen Kerry Shingleton, Alexander William Commun Integr Biol Article Addendum Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size. Taylor & Francis 2014-10-31 /pmc/articles/PMC4594587/ /pubmed/26842847 http://dx.doi.org/10.4161/cib.29240 Text en © 2014 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Article Addendum
Mirth, Christen Kerry
Shingleton, Alexander William
The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila
title The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila
title_full The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila
title_fullStr The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila
title_full_unstemmed The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila
title_short The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila
title_sort roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in drosophila
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594587/
https://www.ncbi.nlm.nih.gov/pubmed/26842847
http://dx.doi.org/10.4161/cib.29240
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