Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor

Reprogramming energy metabolism, such as enhanced glycolysis, is an Achilles' heel in cancer treatment. Most studies have been performed on isolated cancer cells. Here, we studied the energy-transfer mechanism in inflammatory tumor microenvironment. We found that human THP-1 monocytes took up l...

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Detalles Bibliográficos
Autores principales: Wei, Libin, Zhou, Yuxin, Yao, Jing, Qiao, Chen, Ni, Ting, Guo, Ruichen, Guo, Qinglong, Lu, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594635/
https://www.ncbi.nlm.nih.gov/pubmed/25938544

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