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Brachial artery endothelial function is stable across the morning in young men
BACKGROUND: The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594652/ https://www.ncbi.nlm.nih.gov/pubmed/26438100 http://dx.doi.org/10.1186/s12947-015-0036-1 |
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author | Thosar, Saurabh S. Wiggins, Chad C. Shea, Steven A. Wallace, Janet P. |
author_facet | Thosar, Saurabh S. Wiggins, Chad C. Shea, Steven A. Wallace, Janet P. |
author_sort | Thosar, Saurabh S. |
collection | PubMed |
description | BACKGROUND: The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable morning period. METHODS: After overnight fasts, eight healthy men (age 26.3 ± 3 yr) underwent assessments of VEF under standardized testing conditions every 2 h from 0700 to 1300 h on two separate days. VEF was estimated following 5 min brachial artery occlusions by hyperemic flow-mediated dilation (FMD). RESULTS: There was no significant change in FMD or hyperemic shear stimulus across the 6 h vulnerable period on either day, despite changes in physical activity and meals across these periods. CONCLUSION: In this healthy group of young men, VEF is stable across the vulnerable morning period when typical behaviors occurred (breakfast and physical activity). Future research should focus on the roles of sleep, physical inactivity during sleep and endogenous circadian rhythm in VEF. |
format | Online Article Text |
id | pubmed-4594652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45946522015-10-07 Brachial artery endothelial function is stable across the morning in young men Thosar, Saurabh S. Wiggins, Chad C. Shea, Steven A. Wallace, Janet P. Cardiovasc Ultrasound Research BACKGROUND: The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable morning period. METHODS: After overnight fasts, eight healthy men (age 26.3 ± 3 yr) underwent assessments of VEF under standardized testing conditions every 2 h from 0700 to 1300 h on two separate days. VEF was estimated following 5 min brachial artery occlusions by hyperemic flow-mediated dilation (FMD). RESULTS: There was no significant change in FMD or hyperemic shear stimulus across the 6 h vulnerable period on either day, despite changes in physical activity and meals across these periods. CONCLUSION: In this healthy group of young men, VEF is stable across the vulnerable morning period when typical behaviors occurred (breakfast and physical activity). Future research should focus on the roles of sleep, physical inactivity during sleep and endogenous circadian rhythm in VEF. BioMed Central 2015-10-05 /pmc/articles/PMC4594652/ /pubmed/26438100 http://dx.doi.org/10.1186/s12947-015-0036-1 Text en © Thosar et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Thosar, Saurabh S. Wiggins, Chad C. Shea, Steven A. Wallace, Janet P. Brachial artery endothelial function is stable across the morning in young men |
title | Brachial artery endothelial function is stable across the morning in young men |
title_full | Brachial artery endothelial function is stable across the morning in young men |
title_fullStr | Brachial artery endothelial function is stable across the morning in young men |
title_full_unstemmed | Brachial artery endothelial function is stable across the morning in young men |
title_short | Brachial artery endothelial function is stable across the morning in young men |
title_sort | brachial artery endothelial function is stable across the morning in young men |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594652/ https://www.ncbi.nlm.nih.gov/pubmed/26438100 http://dx.doi.org/10.1186/s12947-015-0036-1 |
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