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New circulating biomarkers for predicting cardiovascular death in healthy population

There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CV...

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Autores principales: Melander, Olle, Modrego, Javier, Zamorano-León, Jose J, Santos-Sancho, Juana M, Lahera, Vicente, López-Farré, Antonio J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594690/
https://www.ncbi.nlm.nih.gov/pubmed/26258425
http://dx.doi.org/10.1111/jcmm.12652
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author Melander, Olle
Modrego, Javier
Zamorano-León, Jose J
Santos-Sancho, Juana M
Lahera, Vicente
López-Farré, Antonio J
author_facet Melander, Olle
Modrego, Javier
Zamorano-León, Jose J
Santos-Sancho, Juana M
Lahera, Vicente
López-Farré, Antonio J
author_sort Melander, Olle
collection PubMed
description There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. The study was performed in 82 individuals from the Malmö Diet and Cancer study cohort, free from CVD of whom 41 developed CVD and 41 did not. Plasma proteins related to inflammation and thrombo-coagulating processes were analysed. α1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute cardiovascular episode. Of 82 participants, 17 died by CVD causes. There were proteins whose expression in plasma was significantly higher in participants suffering CVD death as compared with those that did not die by CVD. These proteins included: fibrinogen β-chain isotypes 1 and 3, fibrinogen-γ-chain isotype 2, vitamin D-binding protein isotypes 1, 2 and 3, α1-antitrypsin isotypes 3 and 6, haptoglobin isotypes 3,4,5 and 5, haemopexin isotypes 1 and 2, and Rho/Rac guanine nucleotide exchange factor 2. Moreover, apolipoprotein J plasma levels were found lower in participants that died by cardiovascular cause. Association between plasma levels of proteins and CVD death was independent of age, gender, conventional risk factors and plasma C-reactive protein levels. Several protein plasma levels and protein isotypes related to inflammation and thrombo-coagulating phenomena were independently associated with the risk of future CVD death.
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spelling pubmed-45946902015-10-09 New circulating biomarkers for predicting cardiovascular death in healthy population Melander, Olle Modrego, Javier Zamorano-León, Jose J Santos-Sancho, Juana M Lahera, Vicente López-Farré, Antonio J J Cell Mol Med Original Articles There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. The study was performed in 82 individuals from the Malmö Diet and Cancer study cohort, free from CVD of whom 41 developed CVD and 41 did not. Plasma proteins related to inflammation and thrombo-coagulating processes were analysed. α1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute cardiovascular episode. Of 82 participants, 17 died by CVD causes. There were proteins whose expression in plasma was significantly higher in participants suffering CVD death as compared with those that did not die by CVD. These proteins included: fibrinogen β-chain isotypes 1 and 3, fibrinogen-γ-chain isotype 2, vitamin D-binding protein isotypes 1, 2 and 3, α1-antitrypsin isotypes 3 and 6, haptoglobin isotypes 3,4,5 and 5, haemopexin isotypes 1 and 2, and Rho/Rac guanine nucleotide exchange factor 2. Moreover, apolipoprotein J plasma levels were found lower in participants that died by cardiovascular cause. Association between plasma levels of proteins and CVD death was independent of age, gender, conventional risk factors and plasma C-reactive protein levels. Several protein plasma levels and protein isotypes related to inflammation and thrombo-coagulating phenomena were independently associated with the risk of future CVD death. John Wiley & Sons, Ltd 2015-10 2015-08-10 /pmc/articles/PMC4594690/ /pubmed/26258425 http://dx.doi.org/10.1111/jcmm.12652 Text en © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Melander, Olle
Modrego, Javier
Zamorano-León, Jose J
Santos-Sancho, Juana M
Lahera, Vicente
López-Farré, Antonio J
New circulating biomarkers for predicting cardiovascular death in healthy population
title New circulating biomarkers for predicting cardiovascular death in healthy population
title_full New circulating biomarkers for predicting cardiovascular death in healthy population
title_fullStr New circulating biomarkers for predicting cardiovascular death in healthy population
title_full_unstemmed New circulating biomarkers for predicting cardiovascular death in healthy population
title_short New circulating biomarkers for predicting cardiovascular death in healthy population
title_sort new circulating biomarkers for predicting cardiovascular death in healthy population
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594690/
https://www.ncbi.nlm.nih.gov/pubmed/26258425
http://dx.doi.org/10.1111/jcmm.12652
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