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A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors
AIMS: Clopidogrel and angiotensin converting enzyme (ACE) inhibitors are commonly co-prescribed drugs. Clopidogrel inhibits carboxylesterase 1 (CES1), the enzyme responsible for converting prodrug ACE inhibitors (such as ramipril and perindopril) to their active metabolites. The clinical implication...
Autores principales: | Cressman, Alex M, Macdonald, Erin M, Fernandes, Kimberly A, Gomes, Tara, Paterson, J Michael, Mamdani, Muhammad M, Juurlink, David N |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594702/ https://www.ncbi.nlm.nih.gov/pubmed/25980448 http://dx.doi.org/10.1111/bcp.12682 |
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