Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria

AIMS: The aim was to investigate the QT effect of a single dose combination regimen of piperaquine phosphate (PQP) and a novel aromatic trioxolane, OZ439, for malaria treatment. METHODS: Exposure–response (ER) analysis was performed on data from a placebo-controlled, single dose, study with OZ439 an...

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Detalles Bibliográficos
Autores principales: Darpo, Borje, Ferber, Georg, Siegl, Peter, Laurijssens, Bart, Macintyre, Fiona, Toovey, Stephen, Duparc, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594707/
https://www.ncbi.nlm.nih.gov/pubmed/25966781
http://dx.doi.org/10.1111/bcp.12680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594707/
https://www.ncbi.nlm.nih.gov/pubmed/25966781
http://dx.doi.org/10.1111/bcp.12680

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