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Early innate responses to pathogens: pattern recognition by unconventional human T-cells
Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional huma...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594761/ https://www.ncbi.nlm.nih.gov/pubmed/26182978 http://dx.doi.org/10.1016/j.coi.2015.06.002 |
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author | Liuzzi, Anna Rita McLaren, James E Price, David A Eberl, Matthias |
author_facet | Liuzzi, Anna Rita McLaren, James E Price, David A Eberl, Matthias |
author_sort | Liuzzi, Anna Rita |
collection | PubMed |
description | Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional human T-cells carrying invariant or semi-invariant TCRs that are not restricted by classical MHC molecules sense microbial compounds via entirely novel antigen presenting pathways. This review will focus on the innate-like recognition of non-self metabolites by Vγ9/Vδ2 T-cells, mucosal-associated invariant T (MAIT) cells and germline-encoded mycolyl-reactive (GEM) T-cells, with an emphasis on early immune responses in acute infection. |
format | Online Article Text |
id | pubmed-4594761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45947612015-10-06 Early innate responses to pathogens: pattern recognition by unconventional human T-cells Liuzzi, Anna Rita McLaren, James E Price, David A Eberl, Matthias Curr Opin Immunol Article Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional human T-cells carrying invariant or semi-invariant TCRs that are not restricted by classical MHC molecules sense microbial compounds via entirely novel antigen presenting pathways. This review will focus on the innate-like recognition of non-self metabolites by Vγ9/Vδ2 T-cells, mucosal-associated invariant T (MAIT) cells and germline-encoded mycolyl-reactive (GEM) T-cells, with an emphasis on early immune responses in acute infection. Elsevier 2015-10 /pmc/articles/PMC4594761/ /pubmed/26182978 http://dx.doi.org/10.1016/j.coi.2015.06.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liuzzi, Anna Rita McLaren, James E Price, David A Eberl, Matthias Early innate responses to pathogens: pattern recognition by unconventional human T-cells |
title | Early innate responses to pathogens: pattern recognition by unconventional human T-cells |
title_full | Early innate responses to pathogens: pattern recognition by unconventional human T-cells |
title_fullStr | Early innate responses to pathogens: pattern recognition by unconventional human T-cells |
title_full_unstemmed | Early innate responses to pathogens: pattern recognition by unconventional human T-cells |
title_short | Early innate responses to pathogens: pattern recognition by unconventional human T-cells |
title_sort | early innate responses to pathogens: pattern recognition by unconventional human t-cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594761/ https://www.ncbi.nlm.nih.gov/pubmed/26182978 http://dx.doi.org/10.1016/j.coi.2015.06.002 |
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