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Early innate responses to pathogens: pattern recognition by unconventional human T-cells

Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional huma...

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Detalles Bibliográficos
Autores principales: Liuzzi, Anna Rita, McLaren, James E, Price, David A, Eberl, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594761/
https://www.ncbi.nlm.nih.gov/pubmed/26182978
http://dx.doi.org/10.1016/j.coi.2015.06.002
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author Liuzzi, Anna Rita
McLaren, James E
Price, David A
Eberl, Matthias
author_facet Liuzzi, Anna Rita
McLaren, James E
Price, David A
Eberl, Matthias
author_sort Liuzzi, Anna Rita
collection PubMed
description Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional human T-cells carrying invariant or semi-invariant TCRs that are not restricted by classical MHC molecules sense microbial compounds via entirely novel antigen presenting pathways. This review will focus on the innate-like recognition of non-self metabolites by Vγ9/Vδ2 T-cells, mucosal-associated invariant T (MAIT) cells and germline-encoded mycolyl-reactive (GEM) T-cells, with an emphasis on early immune responses in acute infection.
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spelling pubmed-45947612015-10-06 Early innate responses to pathogens: pattern recognition by unconventional human T-cells Liuzzi, Anna Rita McLaren, James E Price, David A Eberl, Matthias Curr Opin Immunol Article Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional human T-cells carrying invariant or semi-invariant TCRs that are not restricted by classical MHC molecules sense microbial compounds via entirely novel antigen presenting pathways. This review will focus on the innate-like recognition of non-self metabolites by Vγ9/Vδ2 T-cells, mucosal-associated invariant T (MAIT) cells and germline-encoded mycolyl-reactive (GEM) T-cells, with an emphasis on early immune responses in acute infection. Elsevier 2015-10 /pmc/articles/PMC4594761/ /pubmed/26182978 http://dx.doi.org/10.1016/j.coi.2015.06.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liuzzi, Anna Rita
McLaren, James E
Price, David A
Eberl, Matthias
Early innate responses to pathogens: pattern recognition by unconventional human T-cells
title Early innate responses to pathogens: pattern recognition by unconventional human T-cells
title_full Early innate responses to pathogens: pattern recognition by unconventional human T-cells
title_fullStr Early innate responses to pathogens: pattern recognition by unconventional human T-cells
title_full_unstemmed Early innate responses to pathogens: pattern recognition by unconventional human T-cells
title_short Early innate responses to pathogens: pattern recognition by unconventional human T-cells
title_sort early innate responses to pathogens: pattern recognition by unconventional human t-cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594761/
https://www.ncbi.nlm.nih.gov/pubmed/26182978
http://dx.doi.org/10.1016/j.coi.2015.06.002
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