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IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc

BACKGROUND: The purpose of this study is to investigate IL-1β regulation of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-4 and ADAMTS-5) expression through nuclear factor kappa B (NF-κB) in human nucleus pulposus (NP) cells. METHODS: qRT-PCR and Western blot were used to me...

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Detalles Bibliográficos
Autores principales:	Sun, Zhongyi, Yin, Zhanmin, Liu, Chao, Liang, He, Jiang, Minbo, Tian, Jiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594913/ https://www.ncbi.nlm.nih.gov/pubmed/26438479 http://dx.doi.org/10.1186/s13018-015-0296-3

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