Cargando…

Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults

BACKGROUND: Individuals of black African ethnicity tend to have less visceral adipose tissue (VAT) but more subcutaneous-abdominal adipose tissue (SCAT) than white Caucasians. However, it is unclear whether such distribution of abdominal fat is beneficial for metabolic disease risk in black individu...

Descripción completa

Detalles Bibliográficos
Autores principales: De Lucia Rolfe, Emanuella, Ong, Ken K., Sleigh, Alison, Dunger, David B., Norris, Shane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595061/
https://www.ncbi.nlm.nih.gov/pubmed/26437649
http://dx.doi.org/10.1186/s12889-015-2147-x
_version_ 1782393528062574592
author De Lucia Rolfe, Emanuella
Ong, Ken K.
Sleigh, Alison
Dunger, David B.
Norris, Shane A.
author_facet De Lucia Rolfe, Emanuella
Ong, Ken K.
Sleigh, Alison
Dunger, David B.
Norris, Shane A.
author_sort De Lucia Rolfe, Emanuella
collection PubMed
description BACKGROUND: Individuals of black African ethnicity tend to have less visceral adipose tissue (VAT) but more subcutaneous-abdominal adipose tissue (SCAT) than white Caucasians. However, it is unclear whether such distribution of abdominal fat is beneficial for metabolic disease risk in black individuals. Here we compared the associations between these specific abdominal fat depots, insulin sensitivity and metabolic syndrome risk. METHODS: A cross-sectional analysis of 76 black South African young adults (36 men; 40 women) aged 18–19 years participating in the Birth to Twenty Cohort Study had VAT and SCAT measured by MRI. The metabolic syndrome traits (blood pressure, lipid profile, fasting glucose and insulin) were measured and the values were combined into a metabolic syndrome risk score. Fasting glucose and insulin were used to derive the HOMA-index of insulin resistance (HOMA-IR). RESULTS: Compared to men, women had greater VAT (mean: 16.6 vs. 12.5 cm(2)) and SCAT (median 164.0 vs. 59.9 cm(2)). In men, SCAT (r = 0.50) was more strongly correlated to the metabolic syndrome score (MetS) than was VAT (r = 0.23), and was associated with both MetS (P = 0.001) and HOMA-IR (P = 0.001) after adjustment for VAT and total fat mass. In women, both abdominal fat compartments showed comparable positive correlations with MetS (r = 0.26 to 0.31), although these trends were weaker than in men. CONCLUSIONS: In young black South African adults, SCAT appears to be more relevant than VAT to metabolic syndrome traits. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-015-2147-x) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4595061
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-45950612015-10-07 Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults De Lucia Rolfe, Emanuella Ong, Ken K. Sleigh, Alison Dunger, David B. Norris, Shane A. BMC Public Health Research Article BACKGROUND: Individuals of black African ethnicity tend to have less visceral adipose tissue (VAT) but more subcutaneous-abdominal adipose tissue (SCAT) than white Caucasians. However, it is unclear whether such distribution of abdominal fat is beneficial for metabolic disease risk in black individuals. Here we compared the associations between these specific abdominal fat depots, insulin sensitivity and metabolic syndrome risk. METHODS: A cross-sectional analysis of 76 black South African young adults (36 men; 40 women) aged 18–19 years participating in the Birth to Twenty Cohort Study had VAT and SCAT measured by MRI. The metabolic syndrome traits (blood pressure, lipid profile, fasting glucose and insulin) were measured and the values were combined into a metabolic syndrome risk score. Fasting glucose and insulin were used to derive the HOMA-index of insulin resistance (HOMA-IR). RESULTS: Compared to men, women had greater VAT (mean: 16.6 vs. 12.5 cm(2)) and SCAT (median 164.0 vs. 59.9 cm(2)). In men, SCAT (r = 0.50) was more strongly correlated to the metabolic syndrome score (MetS) than was VAT (r = 0.23), and was associated with both MetS (P = 0.001) and HOMA-IR (P = 0.001) after adjustment for VAT and total fat mass. In women, both abdominal fat compartments showed comparable positive correlations with MetS (r = 0.26 to 0.31), although these trends were weaker than in men. CONCLUSIONS: In young black South African adults, SCAT appears to be more relevant than VAT to metabolic syndrome traits. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-015-2147-x) contains supplementary material, which is available to authorized users. BioMed Central 2015-10-05 /pmc/articles/PMC4595061/ /pubmed/26437649 http://dx.doi.org/10.1186/s12889-015-2147-x Text en © De Lucia Rolfe et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
De Lucia Rolfe, Emanuella
Ong, Ken K.
Sleigh, Alison
Dunger, David B.
Norris, Shane A.
Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults
title Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults
title_full Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults
title_fullStr Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults
title_full_unstemmed Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults
title_short Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults
title_sort abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black african young adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595061/
https://www.ncbi.nlm.nih.gov/pubmed/26437649
http://dx.doi.org/10.1186/s12889-015-2147-x
work_keys_str_mv AT deluciarolfeemanuella abdominalfatdepotsassociatedwithinsulinresistanceandmetabolicsyndromeriskfactorsinblackafricanyoungadults
AT ongkenk abdominalfatdepotsassociatedwithinsulinresistanceandmetabolicsyndromeriskfactorsinblackafricanyoungadults
AT sleighalison abdominalfatdepotsassociatedwithinsulinresistanceandmetabolicsyndromeriskfactorsinblackafricanyoungadults
AT dungerdavidb abdominalfatdepotsassociatedwithinsulinresistanceandmetabolicsyndromeriskfactorsinblackafricanyoungadults
AT norrisshanea abdominalfatdepotsassociatedwithinsulinresistanceandmetabolicsyndromeriskfactorsinblackafricanyoungadults