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Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain

Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis cases. Each primary case reported triggered the study of their contacts. Clo...

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Autores principales: Crespo, Inma, Toledo, Diana, Soldevila, Núria, Jordán, Iolanda, Solano, Rubén, Castilla, Jesús, Caylà, Joan A., Godoy, Pere, Muñoz-Almagro, Carmen, Domínguez, Ángela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595087/
https://www.ncbi.nlm.nih.gov/pubmed/26440655
http://dx.doi.org/10.1371/journal.pone.0139993
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author Crespo, Inma
Toledo, Diana
Soldevila, Núria
Jordán, Iolanda
Solano, Rubén
Castilla, Jesús
Caylà, Joan A.
Godoy, Pere
Muñoz-Almagro, Carmen
Domínguez, Ángela
author_facet Crespo, Inma
Toledo, Diana
Soldevila, Núria
Jordán, Iolanda
Solano, Rubén
Castilla, Jesús
Caylà, Joan A.
Godoy, Pere
Muñoz-Almagro, Carmen
Domínguez, Ángela
author_sort Crespo, Inma
collection PubMed
description Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis cases. Each primary case reported triggered the study of their contacts. Close contacts at home and people who were in contact for >2 hours during the transmission period of cases were included. The adjusted OR and 95% confidence intervals (CI) was calculated using logistic regression. A total of 1124 pertussis cases were detected, of which 14.9% were hospitalized. Inspiratory whoop (aOR: 1.64; CI: 1.02–2.65), apnoea (aOR: 2.47; CI: 1.51–4.03) and cyanosis (aOR: 15.51; CI: 1.87–128.09) were more common in hospitalized than in outpatient cases. Hospitalization occurred in 8.7% of correctly-vaccinated cases, 41.1% of non-vaccinated cases and 9.4% of partially-vaccinated cases. In conclusion, inspiratory whoop, apnoea and cyanosis were associated factors to hospitalization while vaccination reduced hospitalizations due to pertussis.
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spelling pubmed-45950872015-10-09 Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain Crespo, Inma Toledo, Diana Soldevila, Núria Jordán, Iolanda Solano, Rubén Castilla, Jesús Caylà, Joan A. Godoy, Pere Muñoz-Almagro, Carmen Domínguez, Ángela PLoS One Research Article Pertussis causes a large number of cases and hospitalizations in Catalonia and Navarra. We made a study of household cases of pertussis during 2012 and 2013 in order to identify risk factors for hospitalization in pertussis cases. Each primary case reported triggered the study of their contacts. Close contacts at home and people who were in contact for >2 hours during the transmission period of cases were included. The adjusted OR and 95% confidence intervals (CI) was calculated using logistic regression. A total of 1124 pertussis cases were detected, of which 14.9% were hospitalized. Inspiratory whoop (aOR: 1.64; CI: 1.02–2.65), apnoea (aOR: 2.47; CI: 1.51–4.03) and cyanosis (aOR: 15.51; CI: 1.87–128.09) were more common in hospitalized than in outpatient cases. Hospitalization occurred in 8.7% of correctly-vaccinated cases, 41.1% of non-vaccinated cases and 9.4% of partially-vaccinated cases. In conclusion, inspiratory whoop, apnoea and cyanosis were associated factors to hospitalization while vaccination reduced hospitalizations due to pertussis. Public Library of Science 2015-10-06 /pmc/articles/PMC4595087/ /pubmed/26440655 http://dx.doi.org/10.1371/journal.pone.0139993 Text en © 2015 Crespo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Crespo, Inma
Toledo, Diana
Soldevila, Núria
Jordán, Iolanda
Solano, Rubén
Castilla, Jesús
Caylà, Joan A.
Godoy, Pere
Muñoz-Almagro, Carmen
Domínguez, Ángela
Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain
title Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain
title_full Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain
title_fullStr Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain
title_full_unstemmed Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain
title_short Characteristics of Hospitalized Cases of Pertussis in Catalonia and Navarra, Two Regions in the North of Spain
title_sort characteristics of hospitalized cases of pertussis in catalonia and navarra, two regions in the north of spain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595087/
https://www.ncbi.nlm.nih.gov/pubmed/26440655
http://dx.doi.org/10.1371/journal.pone.0139993
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