The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis

Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (TLRs) activate a common signaling pathway that involves...

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Detalles Bibliográficos
Autores principales: Wong, Deysi V. T., Lima-Júnior, Roberto C. P., Carvalho, Cibele B. M., Borges, Vanessa F., Wanderley, Carlos W. S., Bem, Amanda X. C., Leite, Caio A. V. G., Teixeira, Maraiza A., Batista, Gabriela L. P., Silva, Rangel L., Cunha, Thiago M., Brito, Gerly A. C., Almeida, Paulo R. C., Cunha, Fernando Q., Ribeiro, Ronaldo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595146/
https://www.ncbi.nlm.nih.gov/pubmed/26440613
http://dx.doi.org/10.1371/journal.pone.0139985

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