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Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia
BACKGROUND: Immune thrombocytopenia (ITP) is an immune-mediated acquired disease that is characterized by a decrease in the platelet count and an increased risk of bleeding. There is little information in the literature about the results of major joint replacement surgery in patients with ITP. The a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595186/ https://www.ncbi.nlm.nih.gov/pubmed/26437678 http://dx.doi.org/10.1186/s12891-015-0742-8 |
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author | Lim, Seung-Jae Yeo, Ingwon Park, Chan-Woo Moon, Young-Wan Park, Youn-Soo |
author_facet | Lim, Seung-Jae Yeo, Ingwon Park, Chan-Woo Moon, Young-Wan Park, Youn-Soo |
author_sort | Lim, Seung-Jae |
collection | PubMed |
description | BACKGROUND: Immune thrombocytopenia (ITP) is an immune-mediated acquired disease that is characterized by a decrease in the platelet count and an increased risk of bleeding. There is little information in the literature about the results of major joint replacement surgery in patients with ITP. The aim of this study was to report on the results of total hip arthroplasty (THA) in patients with primary ITP. METHODS: We retrospectively identified 15 THAs performed in 11 patients with primary ITP. The study group was matched (1:2) to a non-ITP control group of 30 THAs in 22 patients. According to the perioperative hematologic evaluation, blood management interventions were performed. All procedures were performed by a single surgeon and all patients received cementless components with ceramic-on-ceramic bearing. Mean duration of follow-up was 7.1 years (range, 2–13). RESULTS: No significant differences were found between the two groups with regard to mean operative time, intraoperative blood loss, amount of closed suction drainage, length of hospital stay, and readmission rate. However, the proportion of patients requiring transfusion of packed red blood cells and/or platelet concentrate was higher in the ITP group when compared to the non-ITP group. Mean Harris hip score improved from 49.5 points preoperatively to 93.4 points at the final follow-up and no hips were revised for loosening or osteolysis in the ITP group. No significant differences were found between the two groups with respect to mean postoperative Harris hip scores and complication rates. CONCLUSIONS: Our study showed encouraging clinical and radiographic results of THA in patients with ITP without increased risk of adverse events compared to those in patients without ITP. On the basis of these findings, we suggest that modern cementless THA might be a viable treatment for achieving functional improvement in patients with ITP and end-stage hip disease. |
format | Online Article Text |
id | pubmed-4595186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45951862015-10-07 Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia Lim, Seung-Jae Yeo, Ingwon Park, Chan-Woo Moon, Young-Wan Park, Youn-Soo BMC Musculoskelet Disord Research Article BACKGROUND: Immune thrombocytopenia (ITP) is an immune-mediated acquired disease that is characterized by a decrease in the platelet count and an increased risk of bleeding. There is little information in the literature about the results of major joint replacement surgery in patients with ITP. The aim of this study was to report on the results of total hip arthroplasty (THA) in patients with primary ITP. METHODS: We retrospectively identified 15 THAs performed in 11 patients with primary ITP. The study group was matched (1:2) to a non-ITP control group of 30 THAs in 22 patients. According to the perioperative hematologic evaluation, blood management interventions were performed. All procedures were performed by a single surgeon and all patients received cementless components with ceramic-on-ceramic bearing. Mean duration of follow-up was 7.1 years (range, 2–13). RESULTS: No significant differences were found between the two groups with regard to mean operative time, intraoperative blood loss, amount of closed suction drainage, length of hospital stay, and readmission rate. However, the proportion of patients requiring transfusion of packed red blood cells and/or platelet concentrate was higher in the ITP group when compared to the non-ITP group. Mean Harris hip score improved from 49.5 points preoperatively to 93.4 points at the final follow-up and no hips were revised for loosening or osteolysis in the ITP group. No significant differences were found between the two groups with respect to mean postoperative Harris hip scores and complication rates. CONCLUSIONS: Our study showed encouraging clinical and radiographic results of THA in patients with ITP without increased risk of adverse events compared to those in patients without ITP. On the basis of these findings, we suggest that modern cementless THA might be a viable treatment for achieving functional improvement in patients with ITP and end-stage hip disease. BioMed Central 2015-10-05 /pmc/articles/PMC4595186/ /pubmed/26437678 http://dx.doi.org/10.1186/s12891-015-0742-8 Text en © Lim et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lim, Seung-Jae Yeo, Ingwon Park, Chan-Woo Moon, Young-Wan Park, Youn-Soo Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia |
title | Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia |
title_full | Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia |
title_fullStr | Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia |
title_full_unstemmed | Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia |
title_short | Outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia |
title_sort | outcomes of total hip arthroplasty in patients with primary immune thrombocytopenia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595186/ https://www.ncbi.nlm.nih.gov/pubmed/26437678 http://dx.doi.org/10.1186/s12891-015-0742-8 |
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