Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses

How does the body's immune system strike the delicate balance between under- and over-response? A new study shows that glucocorticoids limit the production of the proinflammatory cytokine interleukin-12 by dendritic cells in response to invading bacteria, thereby helping to avoid sepsis. Read t...

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Detalles Bibliográficos
Autor principal: Robinson, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Synopsis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595217/
https://www.ncbi.nlm.nih.gov/pubmed/26441144
http://dx.doi.org/10.1371/journal.pbio.1002270
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author Robinson, Richard
author_facet Robinson, Richard
author_sort Robinson, Richard
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description How does the body's immune system strike the delicate balance between under- and over-response? A new study shows that glucocorticoids limit the production of the proinflammatory cytokine interleukin-12 by dendritic cells in response to invading bacteria, thereby helping to avoid sepsis. Read the Research Article.
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spelling pubmed-45952172015-10-09 Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses Robinson, Richard PLoS Biol Synopsis How does the body's immune system strike the delicate balance between under- and over-response? A new study shows that glucocorticoids limit the production of the proinflammatory cytokine interleukin-12 by dendritic cells in response to invading bacteria, thereby helping to avoid sepsis. Read the Research Article. Public Library of Science 2015-10-06 /pmc/articles/PMC4595217/ /pubmed/26441144 http://dx.doi.org/10.1371/journal.pbio.1002270 Text en © 2015 Richard Robinson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Synopsis
Robinson, Richard
Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses
title Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses
title_full Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses
title_fullStr Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses
title_full_unstemmed Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses
title_short Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses
title_sort glucocorticoids reduce sepsis by diminishing dendritic cell responses
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595217/
https://www.ncbi.nlm.nih.gov/pubmed/26441144
http://dx.doi.org/10.1371/journal.pbio.1002270
work_keys_str_mv AT robinsonrichard glucocorticoidsreducesepsisbydiminishingdendriticcellresponses

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