Genetics ignite focus on microglial inflammation in Alzheimer’s disease

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of...

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Autores principales: Malik, Manasi, Parikh, Ishita, Vasquez, Jared B., Smith, Conor, Tai, Leon, Bu, Guojun, LaDu, Mary Jo, Fardo, David W., Rebeck, G. William, Estus, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595327/
https://www.ncbi.nlm.nih.gov/pubmed/26438529
http://dx.doi.org/10.1186/s13024-015-0048-1
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author Malik, Manasi
Parikh, Ishita
Vasquez, Jared B.
Smith, Conor
Tai, Leon
Bu, Guojun
LaDu, Mary Jo
Fardo, David W.
Rebeck, G. William
Estus, Steven
author_facet Malik, Manasi
Parikh, Ishita
Vasquez, Jared B.
Smith, Conor
Tai, Leon
Bu, Guojun
LaDu, Mary Jo
Fardo, David W.
Rebeck, G. William
Estus, Steven
author_sort Malik, Manasi
collection PubMed
description In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies.  We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.
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spelling pubmed-45953272015-10-08 Genetics ignite focus on microglial inflammation in Alzheimer’s disease Malik, Manasi Parikh, Ishita Vasquez, Jared B. Smith, Conor Tai, Leon Bu, Guojun LaDu, Mary Jo Fardo, David W. Rebeck, G. William Estus, Steven Mol Neurodegener Review In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies.  We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD. BioMed Central 2015-10-05 /pmc/articles/PMC4595327/ /pubmed/26438529 http://dx.doi.org/10.1186/s13024-015-0048-1 Text en © Malik et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Malik, Manasi
Parikh, Ishita
Vasquez, Jared B.
Smith, Conor
Tai, Leon
Bu, Guojun
LaDu, Mary Jo
Fardo, David W.
Rebeck, G. William
Estus, Steven
Genetics ignite focus on microglial inflammation in Alzheimer’s disease
title Genetics ignite focus on microglial inflammation in Alzheimer’s disease
title_full Genetics ignite focus on microglial inflammation in Alzheimer’s disease
title_fullStr Genetics ignite focus on microglial inflammation in Alzheimer’s disease
title_full_unstemmed Genetics ignite focus on microglial inflammation in Alzheimer’s disease
title_short Genetics ignite focus on microglial inflammation in Alzheimer’s disease
title_sort genetics ignite focus on microglial inflammation in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595327/
https://www.ncbi.nlm.nih.gov/pubmed/26438529
http://dx.doi.org/10.1186/s13024-015-0048-1
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